Curcumin Induces Ferroptosis in Follicular Thyroid Cancer by Upregulating HO-1 Expression

Figure 1

The expression of HO-1 is upregulated in FTC. Volcano plots (a) and heatmaps (b) show that the HO-1 expression is upregulated in FTC tissues compared to adjacent tissues. Ca: follicular thyroid cancer tissues; Norm: adjacent normal thyroid tissues. (c) Immunohistochemistry (IHC) results of the HO-1 expression in FTC tissues and adjacent tissues were analyzed by the chi-square test. The black arrows highlight locations where the tunica of tumor cells was invaded, as shown by hematoxylin and eosin (HE) staining. The black head arrows show the expression of HO-1 protein. HE, scale bars: 200 μm; IHC, scale bars: 100 μm. (d) The relative expression of HO-1 is shown as a percentage of the β-actin expression in FTC tissues and adjacent tissues (T: FTC tissues; P: adjacent tissues, ). (e) HO-1 was overexpressed in FTC cells, particularly in FTC-238 cells, compared to Nthy-ori-3-1 cells. , . The data are presented as the (SEM), . Statistical significance was determined by test (d) and one-way ANOVA (e).

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