Research Article

Curcumin Induces Ferroptosis in Follicular Thyroid Cancer by Upregulating HO-1 Expression

Figure 4

Curcumin induces ferroptosis in FTC cells. Curcumin upregulates the expression of HO-1 in FTC cells and triggers ferroptosis. (a, b) Protein expression of HO-1 and GPX4 in FTC cells after treatment with 0, 10, or 20 μM curcumin. β-Actin was used as an internal control. (c–e) Relative iron, GSH, and MDA contents in FTC cells after treatment with 0, 10, or 20 μM curcumin. (f) Determination of lipid ROS levels via fluorescence intensity measurements after treatment with 0, 10, or 20 μM curcumin; scale bars: 50 μm. and compared with the 0 μM curcumin group. The data are presented as the (SEM), . Statistical significance was determined by one-way ANOVA.
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