Inhibition of TRF2 Leads to Ferroptosis, Autophagic Death, and Apoptosis by Causing Telomere Dysfunction

<div>Analysis of TRF2 mRNA expression levels in gastric cancer using bioinformatic databases and TRF2 shRNA knockdown. (a, b) Box plots of the TRF2 mRNA expression levels in gastric cancer tissues and corresponding normal tissues obtained by searching the GEPIA database (a) and TCGA database (b). (c) Survival analysis of gastric cancer patients with high levels of TRF2 mRNA expression and with low levels of TRF2 mRNA expression. (d, e) TRF2 mRNA expression levels and protein expression levels in TRF2 shRNA-transfected cells and scramble shRNA control cells. Each test was repeated in triplicate under the same conditions, and representative data are shown. 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Oxidative Medicine and Cellular Longevity

fig1

Figure 1

Figure 1: Inhibition of TRF2 Leads to Ferroptosis, Autophagic Death, and Apoptosis by Causing Telomere Dysfunction 