Inhibition of TRF2 Leads to Ferroptosis, Autophagic Death, and Apoptosis by Causing Telomere Dysfunction

<div>Effects of TRF2 knockdown on the growth, proliferation, and migration of gastric cancer cells. (a, b) The cell migration ability was detected by scratch-wound healing assays. (c, d) Cell proliferation was detected by colony formation assays. (e) CCK-8 assay growth curves of TRF2 knockdown cells and control cells. (f) Cell viability determined by the trypan blue staining assay. Each test was repeated in triplicate under the same conditions, and representative data are shown. Comparisons were performed using Student’s <span class="nowrap"><svg height="8.02022pt" id="M42" style="vertical-align:-0.2063999pt" version="1.1" viewbox="-0.0498162 -7.81382 4.54925 8.02022" width="4.54925pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M324 430H196L233 583L223 592L145 529L120 430H54L29 396L31 388H111L56 126C33 15 54 -12 77 -12C137 -12 214 57 250 95L233 119C208 92 155 59 138 59C126 59 120 70 131 125L186 390L298 394L324 430Z"></path></g></svg>-</span>test and one-way ANOVA. ns: not significant. <span class="nowrap"><svg height="10.7395pt" id="M43" style="vertical-align:-0.6370001pt" version="1.1" viewbox="-0.0498162 -10.1025 50.9184 10.7395" width="50.9184pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0091,0,0,-0.0091,0,-5.741)"><path d="M486 158C486 177 478 202 466 220C413 228 386 236 336 262C386 288 413 297 466 304C478 323 486 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Oxidative Medicine and Cellular Longevity

fig2

Figure 2

Figure 2: Inhibition of TRF2 Leads to Ferroptosis, Autophagic Death, and Apoptosis by Causing Telomere Dysfunction 