Inhibition of TRF2 Leads to Ferroptosis, Autophagic Death, and Apoptosis by Causing Telomere Dysfunction

<div>Effects of TRF2 knockdown on ferroptosis in gastric cancer cells. (a) The TRF2, p53, and ferroptosis-related protein interaction network was determined using the STRING database. (b, c) The mRNA and protein expression levels of ferroptosis markers were measured by qRT-PCR and Western blotting, respectively. Each test was repeated in triplicate under the same conditions, and representative data are shown. Comparisons were performed using Student’s <span class="nowrap"><svg height="8.02022pt" id="M52" style="vertical-align:-0.2063999pt" version="1.1" viewbox="-0.0498162 -7.81382 4.54925 8.02022" width="4.54925pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M324 430H196L233 583L223 592L145 529L120 430H54L29 396L31 388H111L56 126C33 15 54 -12 77 -12C137 -12 214 57 250 95L233 119C208 92 155 59 138 59C126 59 120 70 131 125L186 390L298 394L324 430Z"></path></g></svg>-</span>test and one-way ANOVA. ns: not significant. <svg height="10.7395pt" id="M53" style="vertical-align:-0.6370001pt" version="1.1" viewbox="-0.0498162 -10.1025 50.9184 10.7395" width="50.9184pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0091,0,0,-0.0091,0,-5.741)"><path d="M486 158C486 177 478 202 466 220C413 228 386 236 336 262C386 288 413 297 466 304C478 323 486 347 485 366C470 376 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Oxidative Medicine and Cellular Longevity

fig5

Figure 5

Figure 5: Inhibition of TRF2 Leads to Ferroptosis, Autophagic Death, and Apoptosis by Causing Telomere Dysfunction 