Increased Iron Levels and Oxidative Stress Mediate Age-Related Impairments in Male and Female Drosophila melanogaster

Figure 8

Proposed hypothesis for Fe-induced damage in aging. Natural aging leads to Fe accumulation and glutathione depletion, this Fe accumulation increases ROS, leading to lipid peroxidation, and glutathione depletion also leads to this damage, occurring ferroptosis that causes changes in behaviors and ultimately fragility and death. DEM worsens locomotor damage and accelerates death.