Enhancing the Neuroprotection Potential of Edaravone in Transient Global Ischemia Treatment with Glutathione- (GSH-) Conjugated Poly(methacrylic acid) Nanogel as a Promising Carrier for Targeted Brain Drug Delivery

Figure 9

The effects of several doses of GSH-PMAA-EDV nanogel (5, 20, 40, and 250 μg/kg) on biochemical alteration. (a) Reduced glutathione level, (b) FRAP level, (c) MDA level, and (d) protein carbonyl amount. Values are expressed as the and were analyzed using one-way ANOVA followed by Bonferroni’s multiple comparison test. , , and compared with the control group. ^#, ^##, and ^### compared with stroke rats, and in case of GSH and FRAP levels, ^$, ^$$, and ^$$$ were compared with the stroke-GSH-PMAA group ().

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