RING Finger Protein 10 Regulates AP-1/Meox2 to Mediate Pirarubicin-Induced Cardiomyocyte Apoptosis

<div>THP causes RNF10 protein and gene abnormalities and cardiomyocyte apoptosis in rat hearts. (a) Immunohistochemistry showed that THP caused a decrease in RNF10 protein expression in rat hearts compared with that in the ND group. (b) TUNEL staining showed that THP caused increased apoptosis of rat cardiomyocytes compared with the ND group. (c) PCR results showed that THP caused a decrease in RNF10 gene expression in rat hearts compared with the ND group. (d, e) WB results showed that compared with the ND group, THP caused the expression of RNF10, Meox2, and Bcl-2/Bax proteins to decrease, while the expression of AP-1 and cleaved caspase-3 proteins increased. 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Oxidative Medicine and Cellular Longevity

fig3

Figure 3

Figure 3: RING Finger Protein 10 Regulates AP-1/Meox2 to Mediate Pirarubicin-Induced Cardiomyocyte Apoptosis 