RING Finger Protein 10 Regulates AP-1/Meox2 to Mediate Pirarubicin-Induced Cardiomyocyte Apoptosis

<div>THP caused H9C2 cardiomyocyte apoptosis and decreased the survival rate. (a) The results of flow cytometry showed that compared with the CON group, THP caused an increase in the apoptosis rate, while the RNF10 silencing group also increased the apoptosis rate. Compared with the THP group, the apoptosis rate of the RNF10 overexpression group decreased significantly. The results of CCK-8 showed that compared with the CON group, THP caused a decrease in cell survival, while the RNF10 silencing group also reduced cell survival (b); compared with the THP group, the cell survival rate of the RNF10 overexpression group was significantly higher (c). 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Oxidative Medicine and Cellular Longevity

fig4

Figure 4

Figure 4: RING Finger Protein 10 Regulates AP-1/Meox2 to Mediate Pirarubicin-Induced Cardiomyocyte Apoptosis 