m6A Modification Mediates Endothelial Cell Responses to Oxidative Stress in Vascular Aging Induced by Low Fluid Shear Stress

Figure 2

The m6A modifications displayed a better dose response to fluid shear stress. (a) PCA plots of the repeated cells exposed to different fluid shear stress. (b) Venn diagrams between differential expressed genes and hypermethylated/hypomethylated genes, respectively. (c) The gene expression of MEGF6 corresponding to different fluid shear stress. (d) Fold changes of m6A modifications on the mRNA of ARHEF12, CBL, KMT2E, RBM12, TRIP12, and ADGRG6, which were corresponding to different fluid shear stress.

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