m6A Modification Mediates Endothelial Cell Responses to Oxidative Stress in Vascular Aging Induced by Low Fluid Shear Stress

Figure 6

Essential roles of the m6A modifications at low FSS in response to oxidative stress. (a) Venn diagram of m6A-modified genes and oxidative stress-related genes. (b) Volcano plots of the m6A-modified oxidative stress-related genes. (c) Heatmap of the m6A-modified oxidative stress-related genes. (d) Bar plot of GO and KEGG database analyses. (e) Circle plot of GO and KEGG database analyses. The hypermethylated and hypomethylated genes were analyzed separately. The annotations of hypermethylated genes were colored in red, and annotations of hypomethylated genes were colored in blue. (f) Interaction network of differentially m6A-modified oxidative stress-related genes. The hypermethylated and hypomethylated genes were colored in red and blue, respectively. The first functional clusters were circled out in yellow. (g) Bar plot of Reactome database analysis. The annotations of hypermethylated genes were colored in red, and annotations of hypomethylated genes were colored in blue.

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