LINC01278 Induces Autophagy to Inhibit Tumour Progression by Suppressing the mTOR Signalling Pathway

Figure 6

LINC01278 suppresses the growth of UM cells by promoting autophagy. (a, e) Western blot analysis of LC3 and P62 in the LV-NC group and LV-LINC01278 group after treatment with DMSO or 3-MA. (b, f) Proliferation analyses of the LV-NC group and LV-LINC01278 group after treatment with DMSO or 3-MA. (c, g) Migration analyses of the LV-NC group and LV-LINC01278 group after treatment with DMSO or 3-MA. (d, h) Invasion analyses of the LV-NC group and LV-LINC01278 group after treatment with DMSO or 3-MA. (i, m) Western blot analysis of LC3 and P62 in the Si-NC group and Si-LINC01278 group after treatment with DMSO or MG-132. (j, n) Proliferation analyses of the Si-NC group and Si-LINC01278 group after treatment with DMSO or MG-132. (k, o) Migration analyses of the Si-NC group and Si-LINC01278 group after treatment with DMSO or MG-132. (l, p) Invasion analyses of the Si-NC group and Si-LINC01278 group after treatment with DMSO or MG-132. (OCM1 cells: (a–d), (i–l); MUM-2B cells: (e–h); (m–p); scale bar: 100 μm; data are presented as the ; ; ns: no significant difference, , , , ).

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