Evaluation of Antidiabetic Effect of Combined Leaf and Seed Extracts of Moringa oleifera (Moringaceae) on Alloxan-Induced Diabetes in Mice: A Biochemical and Histological Study

Figure 11

Histological sections of kidney in the experimental groups. (a) Renal tissue of nondiabetic control mice (G1) with normal histological structure of the renal parenchyma, Bowman’s capsule, glomeruli, and kidney tubules. (b) Kidney tissue of diabetic control mice (G2) showing renal histopathological changes that include vacuolation of the endothelial lining of the glomerular tuft and of the epithelial lining renal tubules. (c) Insulin-treated diabetic mice (G3) showing normal renal tissue structure with no histopathological changes. (d–f) The renal tissue of diabetic mice treated with 500 mg/kg BW/day Moringa oleifera leaf (G4), seed (G5), and combination (G6) extracts, respectively, for 1 month, where mild histopathological changes persisted. (g–i) The renal tissue of diabetic mice treated with 500 mg/kg BW/day Moringa oleifera leaf (G7), seed (G8), and combination (G9) extracts, respectively, for 3 months, with a noticeable decrease in renal histopathological changes (hematoxylin and eosin stained, 400x magnification).