Evaluation of Antidiabetic Effect of Combined Leaf and Seed Extracts of Moringa oleifera (Moringaceae) on Alloxan-Induced Diabetes in Mice: A Biochemical and Histological Study

Table 4

Levels of biochemical parameters in diabetic mice treated for 3 months with 500 mg/kg BW/day Moringa oleifera leaf (G7), seed (G8), and combination (G9) extracts as compared with the percentage (%) change, decrease (▼) or increase (▲), in the diabetic control group (G2)^† and diabetic mice treated for 1 month with Moringa oleifera leaf (G4), seed (G5)^◊, and combination (G6)^‡ extracts.

Biochemical parameter	Experimental mice groups treated with Moringa oleifera for 3 months
	G7		G8		G9
	Value	%	Value	%	Value	%
TG		19%; 23%^†		8%^◊; 2%^†		16%^‡; 28%^†
CT		8%; 16%^†		13%^◊; 4%^†		9%^‡; 20%^†
Creatinine		22%; 45%^†		36%^◊; 7%^†		33%^‡; 61%^†
ALP		12%; 49%^†		4%^◊; 0.4%^†		9%^‡; 51%^†
AST		14%; 26%^†		12%^◊; 5%^†		16%^‡; 32%^†
ALT		14%; 24%^†		12%^◊; 4%^†		16%^‡; 27%^†
MDA		63%; 55%^†		43%^◊; 12%^†		28%^‡; 61%^†
NO		27%; 41%^†		33%^◊; 1.3%^†		33%^‡; 59%^†
PC		43%; 53%		21%^◊; 6%^†		17%^‡; 55%^†
GSH		14%; 30%^†		40%^◊; 13%^†		35%^‡; 46%^†
CAT		17%; 44%^†		48%^◊; 17%^†		27%^‡; 51%^†

TG: triglyceride; CT: cholesterol; ALP: alkaline phosphatase; AST: aspartate aminotransferase; ALT: alanine aminotransferase; MDA: malondialdehyde; NO: nitric oxide; PC: protein carbonyl; GSH: reduced glutathione; CAT: catalase. ^†Compared with diabetic control. Compared with G4. ^◊Compared with G5. ^‡Compared with G6.