Substance P-Mediated Vascular Protection Ameliorates Bone Loss

Figure 5

The early treatment of SP inhibits the loss of angiogenic growth factor and ameliorates systemic inflammation at 8 weeks post-OVX induction. (a) Experiment scheme for OVX and SP treatment. SP was injected intravenously twice a week for 4 weeks, and it was stopped until 8 weeks post-OVX induction. Saline was used as vehicle control. (b) Change of rat body weight at 8 weeks post-OVX induction. The amounts of TNFα (c), IL-10 (d), VEGF (e), and PDGF-BB (f) in serum were measured by ELISA. The amounts of VEGF (g) and PDGF-BB (h) in BM were measured by ELISA. Values are , , , and .

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