Substance P-Mediated Vascular Protection Ameliorates Bone Loss

<div>SP-mediated vascular protection mitigates bone density reduction. (a) The representative images of Masson’s Trichrome (MTC) staining of femoral metaphysis regions. Scale bar: 100 <i>μ</i>m. (b) Representative images of femoral <i>μ</i>CT (c–f). Quantitative analysis of the trabecular bone fraction of the femur at 8 weeks post-OVX induction. 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22C152 22 124 173 124 313S148 602 238 602Z"></path></g><g transform="matrix(.013,0,0,-0.013,46.086,0)"><path d="M113 -12C146 -12 170 11 170 46C170 78 146 103 114 103S58 78 58 46C58 11 82 -12 113 -12Z"></path></g><g transform="matrix(.013,0,0,-0.013,49.05,0)"><path d="M241 635C89 635 35 457 35 312C35 153 89 -12 240 -12C390 -12 443 166 443 312C443 466 390 635 241 635ZM238 602C329 602 354 454 354 312C354 172 330 22 240 22C152 22 124 173 124 313S148 602 238 602Z"></path></g><g transform="matrix(.013,0,0,-0.013,55.29,0)"><path d="M241 635C89 635 35 457 35 312C35 153 89 -12 240 -12C390 -12 443 166 443 312C443 466 390 635 241 635ZM238 602C329 602 354 454 354 312C354 172 330 22 240 22C152 22 124 173 124 313S148 602 238 602Z"></path></g><g transform="matrix(.013,0,0,-0.013,61.53,0)"><path d="M384 0V27C293 34 287 42 287 114V635C232 613 172 594 109 583V559L157 557C201 555 205 550 205 499V114C205 42 199 34 109 27V0H384Z"></path></g></svg>.</span> BV: trabecular bone volume; TV: tissue volume; BS: bone surface; Tb.N: trabecular number; Tb.SP: trabecular separation.</div>

Oxidative Medicine and Cellular Longevity

Substance P-Mediated Vascular Protection Ameliorates Bone Loss

Figure 7