Substance P-Mediated Vascular Protection Ameliorates Bone Loss

Figure 8

SP treatment reduces oxidative stress due to estrogen deficiency at 4 weeks post-OVX. SOD activity in BMA was measured at 3 (a) and 4 (b) weeks post-OVX induction. NO concentration in BMA was measured by the Griess reagent system at 3 (c) and 4 (d) weeks. (e) Experiment scheme for OVX and SP treatment. SP was injected intravenously twice a week for 4 weeks. Saline was used as vehicle control. NO concentration (f) and SOD activity (g) in BM at 4 week post-OVX induction were determined.

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