Chitosan Nanoparticles Alleviated the Adverse Effects of Sildenafil on the Oxidative Stress Markers and Antioxidant Enzyme Activities in Rats

Table 1

Effect of sildenafil, sildenafil-NPs, and Tween 80-coated sildenafil-NPs on the activity of antioxidant enzymes.

Parameter	Control	Sildenafil	Sildenafil NPs	Tween 80-sildenafil NPs
GSH levels (μmol/g liver)
TBARS (μmol/g liver)
GST activity (unit/mg)
GR activity (nmol oxidized NADPH/mg protein/min)
GPx activity [unit/ mg protein]
Catalase activity (μmol H2O2/mg protein/min)
SOD activity (unit/mg protein)

NPs are chitosan nanoparticles. All values are presented as . Means with different superscripts are statistically significant, whereas means with similar superscripts are statistically non-significant ().