Oxidative Medicine and Cellular Longevity

Cellular and Molecular Mechanisms of Oxidative Stress in Stroke

Publishing date
01 Mar 2021
Submission deadline
23 Oct 2020

Lead Editor

1Fudan University, Shanghai, China

2Mie University, Tsu, Japan

3Polish Academy of Sciences, Warsaw, Poland

4Loma Linda University, Loma Linda, USA

Cellular and Molecular Mechanisms of Oxidative Stress in Stroke

Call for papers

This Issue is now open for submissions.

Papers are published upon acceptance, regardless of the Special Issue publication date.

 Submit to this Special Issue


According to a report from the World Health Organization (WHO), stroke now is considered as the second leading cause of death and accounts for about 9% of deaths worldwide each year. It usually causes neurological deficits to patients, threatens people’s health, and increases the burden of medical expenses. Thus, new treatments are urgently needed to improve prognosis and minimize complications.

Studies have found that reactive oxygen species (ROS) have been implicated in brain injury induced by ischemic stroke. There is a rapid increase in the production of ROS immediately after acute ischemic stroke. This overwhelming antioxidant defence would cause further tissue damage. These ROS can damage cellular macromolecules leading to autophagy, apoptosis, and necrosis. However, current measures to protect the brain against severe stroke damage are insufficient. Thus, it is critical to investigate antioxidant strategies that lead to the diminution of oxidative injury.

The aim of this Special Issue is to collate any manuscripts related to the mechanisms involved in ROS generation, the role of oxidative stress in the pathogenesis of ischemic stroke, and the novel therapeutic strategies to be tested to reduce cerebral damage.

Potential topics include but are not limited to the following:

  • Antioxidant strategies that alleviate oxidative injury after stroke
  • Brain haemorrhage and oxidative stress
  • Cell death mechanisms and oxidative stress
  • Endoplasmic reticulum stress and oxidative stress in stroke
  • Genetics of oxidative stress in stroke
  • Global and neonatal brain injury and oxidative stress
  • Neuroinflammation and oxidative stress
  • Novel therapeutic strategies to reduce cerebral damage in stroke
  • Oxidative stress and arteriosclerosis
  • Oxidative stress and lifestyle disease in stroke
  • Oxidative stress and proteasome dysfunction in stroke
  • Oxidative stress and vascular dementia
  • Oxidative stress biomarkers in stroke
  • Oxidative stress mechanisms in stroke
  • Stem cells and oxidative stress in stroke
  • Surgical treatment and oxidative stress


  • Special Issue
  • - Volume 2020
  • - Article ID 7308386
  • - Research Article

Notoginseng Leaf Triterpenes Ameliorates OGD/R-Induced Neuronal Injury via SIRT1/2/3-Foxo3a-MnSOD/PGC-1α Signaling Pathways Mediated by the NAMPT-NAD Pathway

Weijie Xie | Ting Zhu | ... | Xiaobo Sun
  • Special Issue
  • - Volume 2020
  • - Article ID 5609637
  • - Research Article

Hypoxia-Induced Glioma-Derived Exosomal miRNA-199a-3p Promotes Ischemic Injury of Peritumoral Neurons by Inhibiting the mTOR Pathway

Jian-Lan Zhao | Bo Tan | ... | Rong Xie
  • Special Issue
  • - Volume 2020
  • - Article ID 1201624
  • - Research Article

Cholic Acid Protects In Vitro Neurovascular Units against Oxygen and Glucose Deprivation-Induced Injury through the BDNF-TrkB Signaling Pathway

Changxiang Li | Xueqian Wang | ... | Qingguo Wang
  • Special Issue
  • - Volume 2020
  • - Article ID 6801587
  • - Research Article

Rh-CSF1 Attenuates Oxidative Stress and Neuronal Apoptosis via the CSF1R/PLCG2/PKA/UCP2 Signaling Pathway in a Rat Model of Neonatal HIE

Xiao Hu | Shirong Li | ... | John H. Zhang
  • Special Issue
  • - Volume 2020
  • - Article ID 7815325
  • - Research Article

Aescin Protects Neuron from Ischemia-Reperfusion Injury via Regulating the PRAS40/mTOR Signaling Pathway

Xinjie Gao | Heng Yang | ... | Yuxiang Gu
  • Special Issue
  • - Volume 2020
  • - Article ID 7289194
  • - Review Article

Roles of TRP Channels in Neurological Diseases

Rui Wang | Sheng Tu | ... | Anwen Shao
  • Special Issue
  • - Volume 2020
  • - Article ID 3214350
  • - Research Article

A Sphingosine-1-Phosphate Receptor Modulator Attenuated Secondary Brain Injury and Improved Neurological Functions of Mice after ICH

T. Bobinger | T. Bäuerle | ... | A. Manaenko
  • Special Issue
  • - Volume 2020
  • - Article ID 4921562
  • - Research Article

The Activation of Phosphatidylserine/CD36/TGF-β1 Pathway prior to Surgical Brain Injury Attenuates Neuroinflammation in Rats

Lei Huang | Hailiang Tang | ... | John H. Zhang
  • Special Issue
  • - Volume 2020
  • - Article ID 8561609
  • - Research Article

Evaluation of Hemodynamic Change by Indocyanine Green-FLOW 800 Videoangiography Mapping: Prediction of Hyperperfusion Syndrome in Patients with Moyamoya Disease

Xin Zhang | Wei Ni | ... | Yuxiang Gu
Oxidative Medicine and Cellular Longevity
 Journal metrics
Acceptance rate48%
Submission to final decision56 days
Acceptance to publication37 days
Impact Factor5.076

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