Oxidative Medicine and Cellular Longevity

Antioxidants and Cancer: Theories, Techniques, and Trials in Preventing Cancer


Publishing date
01 Jan 2018
Status
Published
Submission deadline
25 Aug 2017

Lead Editor

1Columbia University Medical Center, New York, USA

2Universidad Autónoma de Madrid, Madrid, Spain

3City University of New York, Bronx, USA

4University of Alberta, Edmonton, Canada

5University of Chile, Santiago, Chile


Antioxidants and Cancer: Theories, Techniques, and Trials in Preventing Cancer

Description

The interaction between reactive O2 species (ROS) and inflammasome plays a crucial role in the pathogenesis of oncological and nononcological diseases. Preclinical and clinical studies are flourishing worldwide to support some theories of anticancer preventive strategy using antioxidants. The advancements in biotechnology are transforming the way we diagnose and cure diseases. Recently, a historic moment for the noncommunicable disease community has been reached because world leaders formally adopted the 2030 Agenda for Sustainable Development at the United Nations in New York (USA) with 17 sustainable development goals and 169 targets that will drive efforts to improve health and well-being and protect our planet over the next fifteen years. Trials are being registered and conducted in the clinical community to identify molecules that will be useful for future therapeutic professional guidelines. There is a need of novel, more specific antioxidant and anti-inflammatory approaches aimed at prevention of ROS formation by targeting specific molecular pathways involved in ROS generation and, specifically, their activation of proinflammatory cascades. Oxidative stress can cause arrest or induction of transcription, activation of signaling pathways, and genomic instability. These molecules are key factors that modulate cancer cell proliferation, evasion of apoptosis, contiguous tumor spreading, epithelial mesenchymal transition, tumor angiogenesis, and metastasis.

In this special issue, we are interested in receiving original investigations as well as authoritative narrative or systematic review with or without PRISMA-guided meta-analysis which describe new modalities for strategies in animal models and at clinical level in terms of prevention, diagnosis, and treatment.

Potential topics include but are not limited to the following:

  • ChIP-sequencing
  • Nanoscale trials
  • Analytical chemistry of macromolecules
  • Cancer stem cells driven resistance to chemotherapy for both hematologic cancer and solid cancer
  • ROS, antioxidants
  • Autophagy-modulating mechanisms and drugs
  • Mitophagy nanoregulators
  • Sirtuins-modulators
  • Exploring or discussing the concepts related to prevention and those key factors that modulate the hallmarks of cancer from stem cells to metastasis

Articles

  • Special Issue
  • - Volume 2018
  • - Article ID 5363064
  • - Editorial

Antioxidants and Cancer: Theories, Techniques, and Trials in Preventing Cancer

Gloria M. Calaf | Francisco Aguayo | ... | Debasish Roy
  • Special Issue
  • - Volume 2018
  • - Article ID 6039453
  • - Research Article

Blood and Tissue Enzymatic Activities of GDH and LDH, Index of Glutathione, and Oxidative Stress among Breast Cancer Patients Attending Referral Hospitals of Addis Ababa, Ethiopia: Hospital-Based Comparative Cross-Sectional Study

Mohammed Mehdi | M. K. C. Menon | ... | Daniel Seifu
  • Special Issue
  • - Volume 2017
  • - Article ID 5647281
  • - Research Article

Modulation of Multidrug Resistance Gene Expression by Coumarin Derivatives in Human Leukemic Cells

Tomasz Kubrak | Anna Bogucka-Kocka | ... | Janusz Kocki
  • Special Issue
  • - Volume 2017
  • - Article ID 9369872
  • - Research Article

UPLC-MS/MS Profile of Alkaloids with Cytotoxic Properties of Selected Medicinal Plants of the Berberidaceae and Papaveraceae Families

Anna Och | Katarzyna Szewczyk | ... | Anna Bogucka-Kocka
  • Special Issue
  • - Volume 2017
  • - Article ID 2694945
  • - Research Article

An Extract from the Plant Deschampsia antarctica Protects Fibroblasts from Senescence Induced by Hydrogen Peroxide

Ana Ortiz-Espín | Esther Morel | ... | Francisca Sevilla
  • Special Issue
  • - Volume 2017
  • - Article ID 4674918
  • - Research Article

Quercetin Reverses Rat Liver Preneoplastic Lesions Induced by Chemical Carcinogenesis

Gabriela Carrasco-Torres | Hugo Christian Monroy-Ramírez | ... | Verónica Rocío Vásquez-Garzón
  • Special Issue
  • - Volume 2017
  • - Article ID 1767198
  • - Research Article

Apple Flavonoids Suppress Carcinogen-Induced DNA Damage in Normal Human Bronchial Epithelial Cells

Vazhappilly Cijo George | H. P. Vasantha Rupasinghe
Oxidative Medicine and Cellular Longevity
 Journal metrics
Acceptance rate48%
Submission to final decision74 days
Acceptance to publication36 days
CiteScore4.520
Impact Factor4.868
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