Despite the major developments in the last decades, infertility and pregnancy complications still pose serious burden on women, their families, and the society. Women tend to establish family at older age or with various comorbidities, like chronic inflammatory diseases, type 1 or type 2 diabetes mellitus, organ transplantation, or other conditions, and wish to rely on the development of specialized medicine. These conditions do not only cause short-term health problems during pregnancy but their long-term consequences may also increase, like, among others, metabolic and cardiovascular risk of these women and their offspring. Oxidative signaling and oxidative stress has been previously suggested to play role in fertility and in the course of healthy and complicated pregnancies, such as early fetal development, normal and altered placentation, and pregnancy complications. On the other hand, antioxidant therapies, such as in cardiovascular or metabolic diseases, failed to improve related pathologies in the clinical setting. In order to reveal the real impact of oxidative signaling and oxidative stress in these pathologies and to identify potential related targets having therapeutic or prognostic potentials, further studies are required.

We invite authors to contribute original research articles as well as review articles that will contribute to our better understanding of oxidative signaling and oxidative stress in the process of childbearing; and its short-and long-term impact on women’s and their offspring’s health. We are interested in articles describing novel oxidative signaling pathways or oxidative stress related processes that play a role in the different stages of childbearing: from preconception, through the course of pregnancy, to the long-term consequences. We especially encourage studies identifying novel prognostic or therapeutic targets that may exert beneficial effect in related pathologies.

Potential topics include but are not limited to the following:

• Role of oxidative signaling and oxidative stress in infertility and related diseases, for example, but not limited to cardiovascular, metabolic, endocrine, and malignant diseases
• Role of oxidative signaling and oxidative stress in in vitro fertilization and possible mechanisms that may improve success rate
• Role of oxidative signaling and oxidative stress in the early fetal development and potential mechanisms that may reduce early miscarriages
• Role of oxidative signaling and oxidative stress in the normal course of pregnancy and its role in placental development, immunotolerance, and delivery
• Role of oxidative signaling and oxidative stress in pregnancy-related complications and identification of possible novel prognostic markers and therapeutic targets
• Role of oxidative signaling and oxidative stress in the long-term consequences of childbearing