Oxidative Medicine and Cellular Longevity

Hydrogen Sulfide Signaling in Oxidative Stress and Aging Development


Publishing date
20 Mar 2015
Status
Published
Submission deadline
30 Nov 2014

Lead Editor

1Lakehead University, Thunder Bay, Canada

2Johns Hopkins University, Baltimore, USA

3Nanjing Medical University, Nanjing, China

4Harbin Medical University, Harbin, China

5Shanxi University, Taiyuan, China


Hydrogen Sulfide Signaling in Oxidative Stress and Aging Development

Description

Hydrogen sulfide (H 2S) has emerged to be one important member of the family of gasotransmitters, together with nitric oxide and carbon monoxide. The ubiquitous distribution of H 2S-producing enzymes and the potent chemical reactivities of H 2S in biological system make this molecule unique in regulating cellular and organ functions in both health and diseases. H 2S-induced S-sulfhydration of its targeted proteins is a novel and important signaling mechanism involving the posttranslational modification of proteins. Pathophysiological abnormalities, related to altered H 2S metabolism and function, have been demonstrated in many diseases. H 2S also possesses a great therapeutic potential in age-associated diseases by modulation of oxidative stress. The correlation of H 2S metabolism with physiological and pathophysiological changes that contribute to redox homeostasis and aging has been largely unknown.

We invite investigators to submit original research articles as well as review articles highlighting the novel discoveries and recent progress in relation to H 2S signaling in redox homeostasis, inflammation, cellular energetics, cell growth and apoptosis, interaction with other gasotransmitters, protein and DNA modification, age-related disorders, and so on. The articles that dissect the multitude of H 2S effects at the molecular, cellular, and system levels in humans and various animal disease models are especially welcomed.

Potential topics include, but are not limited to:

  • H 2S signaling in oxidative stress
  • H 2S signaling in cellular senescence and aging development
  • S-sulfhydration regulation of proteins
  • Recent advance on the analytical methods for detection of endogenous H 2S
  • Current strategies to regulate H 2S-producing enzyme and alter H 2S production
  • Development of new H 2S donors and H 2S probes
  • Roles of H 2S in mitochondrial functions
  • Pathological implication of H 2S in humans and animal disease models

Articles

  • Special Issue
  • - Volume 2015
  • - Article ID 397502
  • - Review Article

Physiological Implications of Hydrogen Sulfide in Plants: Pleasant Exploration behind Its Unpleasant Odour

Zhuping Jin | Yanxi Pei
  • Special Issue
  • - Volume 2015
  • - Article ID 927686
  • - Research Article

Superoxide Mediates Depressive Effects Induced by Hydrogen Sulfide in Rostral Ventrolateral Medulla of Spontaneously Hypertensive Rats

Haiyun Yu | Haiyan Xu | ... | Ning Lu
  • Special Issue
  • - Volume 2015
  • - Article ID 925167
  • - Review Article

The Cardioprotective Effects of Hydrogen Sulfide in Heart Diseases: From Molecular Mechanisms to Therapeutic Potential

Yaqi Shen | Zhuqing Shen | ... | Yi Zhun Zhu
  • Special Issue
  • - Volume 2015
  • - Article ID 758358
  • - Research Article

Cardiac H2S Generation Is Reduced in Ageing Diabetic Mice

Sheng Jin | Shi-Xin Pu | ... | Yi-Chun Zhu
  • Special Issue
  • - Volume 2015
  • - Article ID 636410
  • - Research Article

An Anticancer Role of Hydrogen Sulfide in Human Gastric Cancer Cells

Li Zhang | Qi Qi | ... | Rui Wang
  • Special Issue
  • - Volume 2015
  • - Article ID 323269
  • - Review Article

Interaction of H2S with Calcium Permeable Channels and Transporters

Weihua Zhang | Changqing Xu | ... | Rui Wang
  • Special Issue
  • - Volume 2015
  • - Article ID 691070
  • - Research Article

Hydrogen Sulfide Donor GYY4137 Protects against Myocardial Fibrosis

Guoliang Meng | Jinbiao Zhu | ... | Yong Ji
Oxidative Medicine and Cellular Longevity
 Journal metrics
Acceptance rate48%
Submission to final decision56 days
Acceptance to publication37 days
CiteScore7.300
Impact Factor5.076
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