Oxidative Medicine and Cellular Longevity

Modulating Oxidative Stress in Drug-Induced Injury and Metabolic Disorders: The Role of Natural and Synthetic Antioxidants


Publishing date
01 Mar 2019
Status
Published
Submission deadline
19 Oct 2018

1Beni-Suef University, Beni Suef, Egypt

2Manchester Metropolitan University, Manchester, UK

3Detroit R&D Inc., Detroit, USA

4PMAS-Arid Agriculture University, Rawalpindi, Pakistan


Modulating Oxidative Stress in Drug-Induced Injury and Metabolic Disorders: The Role of Natural and Synthetic Antioxidants

Description

Oxidative stress is an imbalance in cellular redox reactions which plays a key role in the pathogenesis of metabolic disorders and drug-induced injury. Oxidative stress is the result of reactive oxygen species (ROS) overproduction or a decline in antioxidant defense mechanisms. Although ROS production can be beneficial in some instances as they are used by the immune system, in general, excessive generation of ROS results in deleterious effects causing damage to DNA, proteins, and lipids, ultimately leading to cell death. Several diseases, including cancer, neurodegeneration, obesity, metabolic syndrome, diabetes mellitus, liver disease, and others, are well-known to be associated with excessive ROS production. Therefore, agents counteracting excess ROS and/or boosting the antioxidant defenses represent an appealing strategy for the treatment of multiple diseases.

Antioxidant substances could be natural or synthetic. Natural antioxidants are obtained entirely from natural sources and have been used in food, cosmetics, and pharmaceutical industries for some time. On the other hand, synthetic antioxidants are substances created from chemical processes. The current understanding of the complex role of ROS in the physiological and pathological processes points to the necessity of developing multifunctional antioxidants, which can maintain oxidative homeostasis, both in health and in disease. In this context, numerous research groups focus on the characterization and application of natural antioxidant agents in different diseases. In addition, a great deal of effort is being conducted to design and synthesize free radical scavenging and antioxidant substances that can diminish excessive ROS production and improve the endogenous antioxidant defenses. Understanding and validating the biological activities of natural and synthetic antioxidant compounds and their molecular mechanisms in counteracting ROS and oxidative stress will provide solid scientific foundation to the application of antioxidants in the prevention and treatment of multiple diseases.

We invite investigators to contribute original research, as well as review articles that illustrate the usefulness of natural and synthetic antioxidants as novel therapeutic approaches to prevent and fight metabolic diseases and drug-induced disorders. The purpose of the special issue will be to focus on articles describing the mechanism underlying the modulatory effect of natural and synthetic antioxidants on oxidative stress.

Potential topics include but are not limited to the following:

  • Role of ROS in metabolic and drug-induced disorders
  • In vitro and in vivo studies on the role of antioxidants in controlling redox imbalance
  • Modulators of the redox-sensitive transcription factors
  • Characterization of the mechanism of action of natural and synthetic antioxidants
  • Natural and synthetic antioxidants as modulators of cellular signaling and metabolism
  • Novel approaches to identify the bioactivity of natural and synthetic antioxidants
  • Therapeutic application of antioxidants in oxidative stress-related diseases

Articles

  • Special Issue
  • - Volume 2019
  • - Article ID 8039694
  • - Research Article

Coenzyme Q10 Ameliorates Pancreatic Fibrosis via the ROS-Triggered mTOR Signaling Pathway

Ran Xue | Jianxin Wang | ... | Jianyu Hao
  • Special Issue
  • - Volume 2019
  • - Article ID 4278658
  • - Review Article

Reactive Oxygen Species Drive Epigenetic Changes in Radiation-Induced Fibrosis

Shashank Shrishrimal | Elizabeth A. Kosmacek | Rebecca E. Oberley-Deegan
  • Special Issue
  • - Volume 2019
  • - Article ID 8549035
  • - Research Article

Proanthocyanidins Antagonize Arsenic-Induced Oxidative Damage and Promote Arsenic Methylation through Activation of the Nrf2 Signaling Pathway

Mengchuan Xu | Qiang Niu | ... | Shugang Li
  • Special Issue
  • - Volume 2019
  • - Article ID 9109473
  • - Review Article

Antioxidant Supplementation in Renal Replacement Therapy Patients: Is There Evidence?

Vassilios Liakopoulos | Stefanos Roumeliotis | ... | Evangelia Dounousi
  • Special Issue
  • - Volume 2019
  • - Article ID 7198484
  • - Research Article

Optimization of Experimental Settings for the Assessment of Reactive Oxygen Species Production by Human Blood

Tânia Soares | Daniela Rodrigues | ... | Marisa Freitas
  • Special Issue
  • - Volume 2018
  • - Article ID 5783239
  • - Research Article

Novel Curcumin C66 That Protects Diabetes-Induced Aortic Damage Was Associated with Suppressing JNK2 and Upregulating Nrf2 Expression and Function

Cheng Li | Xiao Miao | ... | Yonggang Wang
  • Special Issue
  • - Volume 2018
  • - Article ID 7426950
  • - Research Article

Camalexin Induces Apoptosis via the ROS-ER Stress-Mitochondrial Apoptosis Pathway in AML Cells

Yang Yang | Gang Wang | ... | Rui Yu
  • Special Issue
  • - Volume 2018
  • - Article ID 1928945
  • - Research Article

Parenteral Succinate Reduces Systemic ROS Production in Septic Rats, but It Does Not Reduce Creatinine Levels

Sebastián P. Chapela | Isabel Burgos | ... | Carlos A. Stella
  • Special Issue
  • - Volume 2018
  • - Article ID 7845681
  • - Research Article

Thymoquinone Attenuates Cardiomyopathy in Streptozotocin-Treated Diabetic Rats

Mustafa S. Atta | Ali H. El-Far | ... | Shaker A. Mousa
  • Special Issue
  • - Volume 2018
  • - Article ID 3914384
  • - Research Article

Monolluma quadrangula Protects against Oxidative Stress and Modulates LDL Receptor and Fatty Acid Synthase Gene Expression in Hypercholesterolemic Rats

May N. Bin-Jumah
Oxidative Medicine and Cellular Longevity
 Journal metrics
Acceptance rate48%
Submission to final decision56 days
Acceptance to publication37 days
CiteScore7.900
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Impact Factor6.543
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