Oxidative Medicine and Cellular Longevity

Mechanisms and Oxidative Stress in Neuroinflammation


Publishing date
01 Jul 2022
Status
Closed
Submission deadline
18 Feb 2022

1Federal University of Ceará, Fortaleza, Brazil

2University of Glasgow, Glasgow, UK

This issue is now closed for submissions.
More articles will be published in the near future.

Mechanisms and Oxidative Stress in Neuroinflammation

This issue is now closed for submissions.
More articles will be published in the near future.

Description

Inflammation is a complex and coordinated process majorly involved in the innate immune responses to microbial infections and tissue injuries. The complexity of the inflammatory response is observed from different aspects. This includes immune and non-immune cells, which change the microenvironment by producing a plethora of different mediators such as lipid mediators, cytokines and chemokines. These mediators have a central role in all phases of the process. Inflammation in the central nervous system (CNS) plays an important role in neurodegenerative disorders (Parkinson’s and Alzheimer’s diseases). It has been associated with severe inflammatory responses which occur through a variety of cellular and molecular mechanisms, which can include products of oxidative stress.

The current pharmacotherapy mitigating uncontrolled neuroinflammation is mostly anti-inflammatory drugs (steroidal and non-steroidal), immunomodulator agents and biological therapies. However, the continuous use of these agents can reduce efficacy and can potentially have dangerous side effects.

The aim of this Special Issue is to improve our knowledge regarding the cellular and molecular mechanisms of neuroinflammation. We welcome research aiming to improve our understanding of oxidative stress as a pharmacotherapy target mitigating uncontrolled neuroinflammation. Submissions discussing the limitations and advantages of new methods investigating neuroinflammatory responses and oxidative stress are also encouraged. We welcome original research and review articles focusing on either in vitro or in vivo research.

Potential topics include but are not limited to the following:

  • Molecular and cellular mechanisms of neuroinflammation
  • Oxidative stress as a therapeutic target to mitigate uncontrolled neuroinflammation
  • Crosstalk of oxidative stress with others inflammatory mediators in neuroinflammation development
  • Antioxidants in neuroinflammation
  • New methods investigating neuroinflammatory responses and oxidative stress

Articles

  • Special Issue
  • - Volume 2022
  • - Article ID 6125711
  • - Research Article

Preventing Axonal Sodium Overload or Mitochondrial Calcium Uptake Protects Axonal Mitochondria from Oxidative Stress-Induced Alterations

Rebecca Ulshöfer | Helena Bros | ... | Carmen Infante-Duarte
  • Special Issue
  • - Volume 2022
  • - Article ID 7157444
  • - Research Article

Effect of Ethyl Acetate Fraction from Eucommia ulmoides Leaves on PM2.5-Induced Inflammation and Cognitive Dysfunction

Min Ji Kim | Jin Yong Kang | ... | Ho Jin Heo
  • Special Issue
  • - Volume 2022
  • - Article ID 8659587
  • - Research Article

MicroRNA-299a-5p Protects against Spinal Cord Injury through Activating AMPK Pathway

Zong-Ze Zhang | Shu-Yue Xian | ... | Feng Chen
  • Special Issue
  • - Volume 2022
  • - Article ID 4139330
  • - Research Article

URB597 and Andrographolide Improve Brain Microvascular Endothelial Cell Permeability and Apoptosis by Reducing Oxidative Stress and Inflammation Associated with Activation of Nrf2 Signaling in Oxygen-Glucose Deprivation

Da-Peng Wang | Kai Kang | ... | Jian Hai
  • Special Issue
  • - Volume 2022
  • - Article ID 8645714
  • - Research Article

Thioredoxin-Interacting Protein (TXNIP) Knockdown Protects against Sepsis-Induced Brain Injury and Cognitive Decline in Mice by Suppressing Oxidative Stress and Neuroinflammation

Yu Zhang | Cheng-Jun Xing | ... | Jun Zhou
  • Special Issue
  • - Volume 2022
  • - Article ID 6304087
  • - Research Article

Antineuroinflammatory Effect of Amburana cearensis and Its Molecules Coumarin and Amburoside A by Inhibiting the MAPK Signaling Pathway in LPS-Activated BV-2 Microglial Cells

Ana Bruna de Araújo | Francisco Vinícius Clemente Serra Azul | ... | Luzia Kalyne Almeida Moreira Leal
  • Special Issue
  • - Volume 2022
  • - Article ID 4943965
  • - Research Article

Evaluation of Antiarthritic and Antinociceptive Effects of Cedrol in a Rat Model of Arthritis

Fatemeh Forouzanfar | Ali Mohammad Pourbagher-Shahri | Hamed Ghazavi
  • Special Issue
  • - Volume 2022
  • - Article ID 8438528
  • - Research Article

Glycyrrhizin Attenuates Hypoxic-Ischemic Brain Damage by Inhibiting Ferroptosis and Neuroinflammation in Neonatal Rats via the HMGB1/GPX4 Pathway

Kaiyi Zhu | Xing Zhu | ... | Mingyan Hei
  • Special Issue
  • - Volume 2022
  • - Article ID 7907814
  • - Research Article

The Polysaccharides from the Aerial Parts of Bupleurum chinense DC Attenuate Epilepsy-Like Behavior through Oxidative Stress Signaling Pathways

Xiaomao Li | Yan Liu | ... | Bingyou Yang
  • Special Issue
  • - Volume 2021
  • - Article ID 5005136
  • - Review Article

Ferroptosis Mediated by Lipid Reactive Oxygen Species: A Possible Causal Link of Neuroinflammation to Neurological Disorders

Ying Cheng | Yiting Song | ... | Chengliang Luo
Oxidative Medicine and Cellular Longevity
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Article of the Year Award: Outstanding research contributions of 2021, as selected by our Chief Editors. Read the winning articles.