Oxidative Medicine and Cellular Longevity

Redox Homeostasis and Cancer


Publishing date
01 Jan 2020
Status
Closed
Submission deadline
06 Sep 2019

Lead Editor

1Indiana University School of Medicine, Indianapolis, USA

2Royal Institute of Technology, Stockholm, Sweden

3The Ohio State University Medical Center, Columbus, USA

This issue is now closed for submissions.
More articles will be published in the near future.

Redox Homeostasis and Cancer

This issue is now closed for submissions.
More articles will be published in the near future.

Description

Under physiological conditions, a balance between oxidants and antioxidants exists. Reactive oxygen species (ROS) are continuously generated by aerobic cells and eliminated through scavenging systems to maintain redox homeostasis. Disruption of redox homeostasis results in oxidative stress and altered ROS signaling. Higher ROS levels can lead to DNA mutation and genomic instability which can play causal role in cancer development and progression. These mutations, coupled with distorted redox signaling pathways, orchestrate pathologic events inside cancer cells resulting in resistance to stress and death signals, aberrant proliferation, and inefficient repair mechanisms.

Cancer cells are energy hungry, owing to their high rate of proliferation. However, due to impaired TCA cycle and poor blood perfusion, cancer cells switch towards a glycolytic pathway for energy generation termed as ‘Warburg effect’. Such pathways lead to higher oxidative environment. The oxidative environment is also enhanced by tumor-infiltrating macrophages and neutrophils. Thus cancer cells are used to a high ROS environment. This redox imbalance allows protumorigenic cell signaling.

In this issue, we explore the relation between ROS and cancer. Although ROS sustain tumorigenesis and cancer progression, these can also be efficient therapeutic tools to fight cancer. Oxidative stress based therapies, like radiotherapy, chemotherapeutic agents, and photodynamic theory, increase ROS levels in the tumor niche, taking advantage of the cytotoxic face of ROS for killing tumor cells through a sudden, localized, and intense oxidative burst. Clinical efficacy of anticancer therapies is often subdued by multidrug resistance (MDR). Redox therapy, using redox-active drugs or inhibitors of inducible antioxidant defense in the tumor microenvironment, has been reported to be effective against MDR tumors.

In light of these developments, we invite authors to contribute original research articles, as well as review articles, exploring the role of redox and its regulation in cancer.

Potential topics include but are not limited to the following:

  • Reactive oxygen species (ROS) mediated genomic and epigenomic instability
  • Redox signaling as a driving force for epigenetic modifications
  • Transcriptional regulation of Warburg effect
  • Redox and metabolic circuits in cancer
  • Role of tumor infiltrating macrophages and neutrophils in the cancer redox environment
  • Redox signaling for overcoming multidrug resistance in cancer chemotherapy
  • Dietary antioxidants and cancer prognosis
  • Role of redox in cancer caused by ionizing radiation
  • Oxidative stress induced by conventional anticancer therapy using ionizing radiation
  • Role of redox associated noncoding RNAs in the etiology of cancer
  • Oxidative stress and estrogen receptor-associated breast carcinogenesis
  • Mitochondrial targeted compounds towards cancer cells

Articles

  • Special Issue
  • - Volume 2019
  • - Article ID 4120379
  • - Research Article

Presence of Stromal Cells Enhances Epithelial-to-Mesenchymal Transition (EMT) Induction in Lung Bronchial Epithelium after Protracted Exposure to Oxidative Stress of Gamma Radiation

Anna Acheva | Siamak Haghdoost | ... | Meerit Kämäräinen
  • Special Issue
  • - Volume 2019
  • - Article ID 2647068
  • - Research Article

NRF1 and NRF2 mRNA and Protein Expression Decrease Early during Melanoma Carcinogenesis: An Insight into Survival and MicroRNAs

Mari Hämäläinen | Hanna-Riikka Teppo | ... | Peeter Karihtala
  • Special Issue
  • - Volume 2019
  • - Article ID 6470950
  • - Research Article

Nitric Oxide Metabolites and Lung Cancer Incidence: A Matched Case-Control Study Nested in the ESTHER Cohort

Xīn Gào | Yang Xuan | ... | Ben Schöttker
  • Special Issue
  • - Volume 2019
  • - Article ID 8547846
  • - Review Article

Hypoxia-Inducible Factors as an Alternative Source of Treatment Strategy for Cancer

Musbau Adewumi Akanji | Damilare Rotimi | Oluyomi Stephen Adeyemi
  • Special Issue
  • - Volume 2019
  • - Article ID 6793957
  • - Research Article

Prooxidative Activity of Celastrol Induces Apoptosis, DNA Damage, and Cell Cycle Arrest in Drug-Resistant Human Colon Cancer Cells

Helena Moreira | Anna Szyjka | ... | Ewa Barg
  • Special Issue
  • - Volume 2019
  • - Article ID 5357649
  • - Research Article

Label-Free Proteomics Revealed Oxidative Stress and Inflammation as Factors That Enhance Chemoresistance in Luminal Breast Cancer

Bruno R. B. Pires | Carolina Panis | ... | Eliana Abdelhay
  • Special Issue
  • - Volume 2019
  • - Article ID 6315034
  • - Review Article

Neuroglobin: A Novel Player in the Oxidative Stress Response of Cancer Cells

Marco Fiocchetti | Virginia Solar Fernandez | ... | Maria Marino
  • Special Issue
  • - Volume 2019
  • - Article ID 3150145
  • - Review Article

Unraveling the Potential Role of Glutathione in Multiple Forms of Cell Death in Cancer Therapy

Huanhuan Lv | Chenxiao Zhen | ... | Peng Shang
  • Special Issue
  • - Volume 2019
  • - Article ID 3264858
  • - Research Article

The NADPH Oxidase Nox4 Controls Macrophage Polarization in an NFκB-Dependent Manner

V. Helfinger | K. Palfi | ... | K. Schröder
Oxidative Medicine and Cellular Longevity
 Journal metrics
Acceptance rate48%
Submission to final decision56 days
Acceptance to publication37 days
CiteScore7.300
Impact Factor5.076
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