Oxidative Medicine and Cellular Longevity

Oxidative Stress and Exosomes in Aging Disease


Publishing date
01 Jan 2022
Status
Closed
Submission deadline
20 Aug 2021

Lead Editor

1Huazhong University of Science and Technology, Wuhan, China

2Tongji University, Shanghai, China

3Harvard Medical College, Boston, USA

This issue is now closed for submissions.
More articles will be published in the near future.

Oxidative Stress and Exosomes in Aging Disease

This issue is now closed for submissions.
More articles will be published in the near future.

Description

Oxidative stress is related to the onset of several pathologies occurring in elderly people and the triggering of inflammatory responses, including diabetes, osteoporosis, metabolic abnormalities, and cancer. Exosomes are small vesicles secreted into circulation by a range of cell types in vivo, whereupon they can be internalized by proximal or distal cells. Exosomes isolated from certain cell types have previously been shown to be capable of ameliorating oxidative stress and aging-related degeneration, but the specific mechanism still remains uncertain. Therefore, new insight into exosomes is needed for the development of new and effective treatments for aging-related diseases.

The generation and elimination of free radicals is in a state of dynamic balance, which is destroyed as the body ages. The chain of free radical reactions induces in DNA, proteins, and especially macromolecular material, such as polyunsaturated fatty acids, degeneration and crosslinking, which is responsible for influencing and modifying surrounding cells. The therapeutic use of agents able to counteract oxidative stress and to modulate and ultimately eliminate senescent cells may represent a crucial strategy for the prevention and treatment of aging diseases.

The aim of this Special Issue, therefore, is to investigate the critical role that exosomes play in regulating oxidative stress, cell death, and inflammation in aging diseases, and to explore their potential as promising therapeutic targets for future treatments of aging diseases. Papers investigating the molecular mechanisms of oxidative stress in aging diseases are welcome. We welcome both original research and review articles.

Potential topics include but are not limited to the following:

  • Molecular mechanisms of oxidative stress and exosomes in aging diseases
  • The role of oxidative stress and exosomes in cell death and disease
  • The interaction of exosome-regulated oxidative stress and autophagy in aging diseases
  • Exosome or exosomal non-coding RNAs in the regulation of oxidative stress
  • Advanced exosome-based treatments for age-related diseases
  • Exosomes in the prevention of cancer by inhibiting oxidative stress
  • Exosomes in cellular senescence and oxidative stress
  • Application of engineering exosomes in the regulation of oxidative stress
  • Exosome-based drugs for oxidative stress in aging disease

Articles

  • Special Issue
  • - Volume 2021
  • - Article ID 9306760
  • - Research Article

MicroRNA-133b Inhibition Restores EGFR Expression and Accelerates Diabetes-Impaired Wound Healing

Haobo Zhong | Jin Qian | ... | Zhiming Zhao
  • Special Issue
  • - Volume 2021
  • - Article ID 2310025
  • - Research Article

Exosomes Derived from Bone Mesenchymal Stem Cells Alleviate Compression-Induced Nucleus Pulposus Cell Apoptosis by Inhibiting Oxidative Stress

Yiqiang Hu | Ranyang Tao | ... | Guohui Liu
  • Special Issue
  • - Volume 2021
  • - Article ID 2094665
  • - Research Article

Periodontitis Exacerbates Benign Prostatic Hyperplasia through Regulation of Oxidative Stress and Inflammation

Cheng Fang | Lan Wu | ... | Xian-Tao Zeng
  • Special Issue
  • - Volume 2021
  • - Article ID 4539453
  • - Review Article

Mesenchymal Stem Cell-Derived Exosomes and Their Potential Agents in Hematological Diseases

Min Shen | Tong Chen
  • Special Issue
  • - Volume 2021
  • - Article ID 6324912
  • - Review Article

Exosome: Function and Application in Inflammatory Bone Diseases

Yingkun Hu | Yi Wang | ... | Jingfeng Li
  • Special Issue
  • - Volume 2021
  • - Article ID 1695087
  • - Research Article

Microglia-Derived Exosomes Improve Spinal Cord Functional Recovery after Injury via Inhibiting Oxidative Stress and Promoting the Survival and Function of Endothelia Cells

Wei Peng | Liyang Wan | ... | Jianzhong Hu
  • Special Issue
  • - Volume 2021
  • - Article ID 9674809
  • - Research Article

Platelet-Rich Plasma-Derived Exosomal USP15 Promotes Cutaneous Wound Healing via Deubiquitinating EIF4A1

Yan Xu | Ze Lin | ... | Deyu Duan
  • Special Issue
  • - Volume 2021
  • - Article ID 6301433
  • - Review Article

Role of Exosomal MicroRNAs and Their Crosstalk with Oxidative Stress in the Pathogenesis of Osteoporosis

Jun Lu | Yan Zhang | ... | Hongmou Zhao
Oxidative Medicine and Cellular Longevity
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Acceptance rate33%
Submission to final decision83 days
Acceptance to publication26 days
CiteScore9.300
Journal Citation Indicator0.730
Impact Factor7.310
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Article of the Year Award: Outstanding research contributions of 2021, as selected by our Chief Editors. Read the winning articles.