Oxidative Medicine and Cellular Longevity

Harmful and Beneficial Role of ROS


Publishing date
13 May 2016
Status
Published
Submission deadline
25 Dec 2015

Lead Editor

1Universita degli Studi di Napoli Federico II, Naples, Italy

2Eastern Kentucky University, Richmond, USA

3Universitat de València, Valencia, Spain


Harmful and Beneficial Role of ROS

Description

It is long known that reactive oxygen species (ROS) are an unavoidable by-product of oxygen metabolism and their cellular concentrations are determined by the balance between their rates of production and their rates of clearance by various antioxidant compounds and enzymes. For a decade or two after the discovery of their presence in biological materials, ROS were thought to cause exclusively toxic effects and were associated with various pathologies. Indeed, when ROS overwhelm the cellular antioxidant defense system, oxidative stress occurs, which results in oxidative damage of nucleic acids, proteins, and lipids. This potentially harmful effect of ROS has been implicated in carcinogenesis, neurodegeneration, atherosclerosis, diabetes, and aging. However, in time the view has been formulated that the presence of ROS in cells indicates that ROS production was evolutionarily selected in order to perform some useful roles.

This view was supported by increasing evidence that while prolonged exposure to high ROS concentrations may lead, through oxidative damage of cellular constituents, to various disorders, low ROS concentrations exert their effects rather through regulation of cell signaling cascades. Indeed, ROS have important functions in cellular signaling as participants and modifiers of signaling pathways, essential for the proper development and proliferation of cells, may have mitogenic effects and can mimic and amplify the action of growth factors. Moreover, it is apparent that biological specificity of ROS action is achieved through the amount, duration, and localization of ROS production. To date, although major ROS-sensitive signal transduction pathways involved in adaptive responses have been shown, a lot remains to be understood about their mutual interaction and the modifications during ageing and some disease states.

Because of the relevance of such topics, it appears appropriate to summarize some of the main recent advances on ROS production and their harmful and beneficial role in the living organisms, mainly focusing attention on their impact on health, diseases, and ageing.

We invite authors to submit original researches and review articles that seek to refine the aforementioned topics.

Potential topics include, but are not limited to:

  • Positive feedback loop in ROS production
  • Interaction among cellular sources of ROS production
  • Hormetic effects of ROS
  • Oxidative and antioxidative stress
  • New insight into the relationship between oxidative stress and ageing
  • Role of oxidative stress in neurodegenerative and cardiovascular diseases
  • Signaling pathways of ROS action

Articles

  • Special Issue
  • - Volume 2016
  • - Article ID 7909186
  • - Editorial

Harmful and Beneficial Role of ROS

Sergio Di Meo | Tanea T. Reed | ... | Victor M. Victor
  • Special Issue
  • - Volume 2016
  • - Article ID 9895245
  • - Research Article

Functionalized Fullerene Increases NF-κB Activity and Blocks Genotoxic Effect of Oxidative Stress in Serum-Starving Human Embryo Lung Diploid Fibroblasts

E. S. Ershova | V. A. Sergeeva | ... | S. V. Kostyuk
  • Special Issue
  • - Volume 2016
  • - Article ID 1245049
  • - Review Article

Role of ROS and RNS Sources in Physiological and Pathological Conditions

Sergio Di Meo | Tanea T. Reed | ... | Victor Manuel Victor
  • Special Issue
  • - Volume 2016
  • - Article ID 8962763
  • - Clinical Study

Influence of Insulin Resistance and TNF-α on the Inflammatory Process, Oxidative Stress, and Disease Activity in Patients with Rheumatoid Arthritis

Neide Tomimura Costa | Tatiana Mayumi Veiga Iriyoda | ... | Andréa Name Colado Simão
  • Special Issue
  • - Volume 2016
  • - Article ID 9685257
  • - Research Article

Antidiabetic and Antinephritic Activities of Aqueous Extract of Cordyceps militaris Fruit Body in Diet-Streptozotocin-Induced Diabetic Sprague Dawley Rats

Chungang Liu | Jingjing Song | ... | Di Wang
  • Special Issue
  • - Volume 2016
  • - Article ID 9814038
  • - Research Article

The Regulatory Role of Nuclear Factor Kappa B in the Heart of Hereditary Hypertriglyceridemic Rat

Stanislava Vranková | Andrej Barta | ... | Josef Zicha
  • Special Issue
  • - Volume 2016
  • - Article ID 3075695
  • - Review Article

Widening and Elaboration of Consecutive Research into Therapeutic Antioxidant Enzyme Derivatives

Alexander V. Maksimenko
  • Special Issue
  • - Volume 2016
  • - Article ID 6298515
  • - Research Article

Induction Effect of Bisphenol A on Gene Expression Involving Hepatic Oxidative Stress in Rat

Sohrab Kazemi | Seydeh Narges Mousavi | ... | Ali Akbar Moghadamnia
  • Special Issue
  • - Volume 2016
  • - Article ID 2795090
  • - Review Article

The Reactive Oxygen Species in Macrophage Polarization: Reflecting Its Dual Role in Progression and Treatment of Human Diseases

Hor-Yue Tan | Ning Wang | ... | Yibin Feng
  • Special Issue
  • - Volume 2016
  • - Article ID 2183026
  • - Review Article

ROS-Mediated NLRP3 Inflammasome Activation in Brain, Heart, Kidney, and Testis Ischemia/Reperfusion Injury

Letteria Minutoli | Domenico Puzzolo | ... | Domenica Altavilla
Oxidative Medicine and Cellular Longevity
 Journal metrics
Acceptance rate48%
Submission to final decision56 days
Acceptance to publication37 days
CiteScore7.300
Impact Factor5.076
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