Oxidative Medicine and Cellular Longevity

Phytochemicals in Cardiovascular and Respiratory Diseases: Evidence in Oxidative Stress and Inflammation


Status
Published

Lead Editor

1“Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania

2University of Salerno, Salerno, Italy

3Imperial College London, London, UK


Phytochemicals in Cardiovascular and Respiratory Diseases: Evidence in Oxidative Stress and Inflammation

Description

It is well known that oxidative stress and long-term inflammatory processes are simultaneously involved in the pathogenesis of various chronic diseases. Furthermore, it is very difficult to predict the primary sources of damage (oxidation or inflammation) since these pathophysiological processes are strongly interconnected. Thus, if oxidative stress occurs first, inflammation processes will be detected at some point as well. The central mechanism responsible for the inflammation initiation is the activation of transcription factor NF-κB This consequently regulates gene expression for proinflammatory cytokines, chemokines, and adhesion molecules. On the other hand, if inflammatory processes occur first, the reactive species resulting from oxidation processes of phagocytic cells or as response to proinflammatory cytokines will be detected. Both excessive oxidative stress and chronic inflammation are present in the pathogenesis of respiratory and cardiovascular chronic diseases. Increasing efforts are observed each year in different interconnected areas like chemistry, medicine, biology, bioinformatics, and others in order to prevent, control, or block disease progression. Still, cardiovascular and respiratory disorders remain the most common cause of mortality worldwide (26 % and 8.61% out of total deaths for cardiovascular and respiratory diseases, resp.). Therefore, more effort is needed targeting different approaches in order to come to a resolution. In these sense, in vivo and in vitro studies already confirmed that phytochemicals intake (e.g., nutraceuticals, fresh fruits, vegetables, or spices) has the potential to lower CVD and respiratory risks by targeting oxidative stress and inflammatory mediators. Transposed into everyday life, supplementation with plants and natural extracts by patients without specific medical advice is a common practice as well. Considering these, more evidence is needed to understand the exact mechanisms of initiation and disease progression in relation to both oxidation and inflammatory processes. This will lead to a safe and efficient usage of phytochemicals in everyday life, expanding their application from the experimental field to real life.

We invite authors to submit original research articles (in vitro, experimental, and clinical studies), as well as review articles, that address the special issue of phytochemicals targeting oxidative stress and inflammation in cardiovascular and respiratory diseases.

Potential topics include but are not limited to the following:

  • Characterization and identification of new phytochemicals of natural origin useful in the development of new drug for CVD or respiratory diseases
  • Oxidative stress, inflammation, and phytochemicals: evidence based impact on the molecular mechanism involved in the initiation, progression, and disease control
  • Phytochemicals evaluation (in vitro or in vivo studies on animals and humans), in relation to inflammation and oxidative stress signaling
  • Markers of oxidative stress and inflammation in the development and progression of cardiovascular and respiratory diseases
  • Phytochemicals effect on specific gene marker expression in CVD and respiratory diseases

Articles

  • Special Issue
  • - Volume 2018
  • - Article ID 1603872
  • - Editorial

Phytochemicals in Cardiovascular and Respiratory Diseases: Evidence in Oxidative Stress and Inflammation

Raluca M. Pop | Ada Popolo | ... | Luminita A. Stanciu
  • Special Issue
  • - Volume 2018
  • - Article ID 2879793
  • - Research Article

Phytochemical Analysis of Anti-Inflammatory and Antioxidant Effects of Mahonia aquifolium Flower and Fruit Extracts

Andra-Diana Andreicut | Alina Elena Pârvu | ... | Alexandru Irimie
  • Special Issue
  • - Volume 2018
  • - Article ID 2504305
  • - Research Article

Anti-Inflammatory Activity of Boswellia serrata Extracts: An In Vitro Study on Porcine Aortic Endothelial Cells

Martina Bertocchi | Gloria Isani | ... | Chiara Bernardini
  • Special Issue
  • - Volume 2018
  • - Article ID 3718437
  • - Research Article

How Could We Influence Systemic Inflammation in Allergic Rhinitis? The Role of H1 Antihistamines

Ioana Adriana Muntean | Ioana Corina Bocsan | ... | Diana Deleanu
  • Special Issue
  • - Volume 2018
  • - Article ID 1583212
  • - Research Article

Chemerin, Inflammatory, and Nitrooxidative Stress Marker Changes Six Months after Sleeve Gastrectomy

Adriana Florinela Cӑtoi | Alina Elena Pârvu | ... | Cornel Cӑtoi
  • Special Issue
  • - Volume 2018
  • - Article ID 3491703
  • - Research Article

Ganoderma Triterpenoids Exert Antiatherogenic Effects in Mice by Alleviating Disturbed Flow-Induced Oxidative Stress and Inflammation

Pei-Ling Hsu | Yung-Ching Lin | ... | Fan-E Mo
  • Special Issue
  • - Volume 2018
  • - Article ID 8194721
  • - Research Article

Polyphenolic Compounds, Antioxidant, and Cardioprotective Effects of Pomace Extracts from Fetească Neagră Cultivar

Ştefania Silvia Balea | Alina Elena Pârvu | ... | Marcel Pârvu
  • Special Issue
  • - Volume 2018
  • - Article ID 7293861
  • - Review Article

SIRT3: A New Regulator of Cardiovascular Diseases

Wei Sun | Caixia Liu | ... | Bin Liu
Oxidative Medicine and Cellular Longevity
 Journal metrics
Acceptance rate48%
Submission to final decision56 days
Acceptance to publication37 days
CiteScore7.300
Impact Factor5.076
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