Oxidative Medicine and Cellular Longevity

Exposomic Fingerprint in the Development of Diseases: the Role of Free Radicals and Multi-Omics


Publishing date
01 Aug 2021
Status
Closed
Submission deadline
19 Mar 2021

Lead Editor

1University of Niš, Niš, Serbia

2University of Ljubljana, Ljubljana, Slovenia

This issue is now closed for submissions.
More articles will be published in the near future.

Exposomic Fingerprint in the Development of Diseases: the Role of Free Radicals and Multi-Omics

This issue is now closed for submissions.
More articles will be published in the near future.

Description

A lifelong exposure to environmental factors, particularly to environmental pollution, may have a profound influence on the human (epi)genome, transcriptome, proteome, and metabolome. While their influence is indisputable, the specific validation (exposome) takes a long time to develop, without a prediction of how significant it will be. In recent years, through the use of advanced scientific tools, the multi-omic approach has become a key area of both fundamental and translational approaches in studying the development of chronic non-communicable human diseases. Providing molecular mechanisms of how specific environmental factors provoke free radical production or how free radicals, as a part of environmental pollution, can affect human health, while contributing to the onset of a specific disease, is a matter of great research. In recent research into chronic disease development, emphasis has been placed on understanding the natural history of the diseases by understanding the factors of individual sensitivity, with a focus on the ways in which the oxidative stress within the body can be balanced and on how proper nutrition, new drugs, or lifestyle can affect the body’s response.

Starting from the definition of a fingerprint as “the impression taken for the purpose of identification and characteristic revealing origin”, potential originality lies in the ability to accurately distinguish and recognize the earliest and innovative exposomic biomarkers, the earliest surrogate markers, and new theranostic markers in disease diagnostics, prevention, and treatment. Translated into the multi-omics language, it is necessary – through the accurate laboratory diagnostics – to determine whether the current diagnostic tool may be considered a reflection of the early development of a disease and may eventuate in the specific disease cascade so that it can be declared a valid biomarker. A step forward is surrogate markers, reflecting the disease stage and progression, while the theranostic markers are the integrated targeted therapies, representing the management of the disease through the specific response to therapeutic intervention or alternative treatment options in chronic diseases and carcinogenesis.

The aim of this Special Issue is to collate articles related to the role of free radicals and multi-omics in describing exposomic marker and other biomarkers of disease. Potential research topics are focused on surrogate markers, theranostic markers, and personalised therapeutic and nutritional regimen for multi-omics induced disease prevention and treatment. Original research and review articles are welcome.

Potential topics include but are not limited to the following:

  • Translational studies using human tissue and blood samples
  • In vivo experimental animal models of free radical-induced chronic diseases
  • In vitro cell culture models of free radical-induced chronic diseases
  • In vitro structure-based new drug design in treating and preventing free radical-induced chronic diseases
  • Identification and characterization of cell signaling pathways sensing exposomic signals originating outside of the cell
  • Identification and characterization of novel regulatory pathways connecting redox-sensitive signalling with signal transduction kinases to cell transcriptome and proteome
  • “microRNomics” and non-coding RNAs metabolism connection with free radicals in chronic diseases and carcinogenesis
  • Identification of oxidatively-modified biomolecules, enzymes, and metabolites as epigenetic and epitranscriptomic modulators

Articles

  • Special Issue
  • - Volume 2021
  • - Article ID 6654388
  • - Research Article

Development and Validation of a Multivariable Predictive Model for Mortality of COVID-19 Patients Demanding High Oxygen Flow at Admission to ICU: AIDA Score

Marija Zdravkovic | Viseslav Popadic | ... | Natasa Milic
  • Special Issue
  • - Volume 2021
  • - Article ID 9986299
  • - Research Article

Changes in Key Mitochondrial Lipids Accompany Mitochondrial Dysfunction and Oxidative Stress in NAFLD

Manon Durand | Marine Coué | ... | David Jacobi
  • Special Issue
  • - Volume 2021
  • - Article ID 6648199
  • - Research Article

Predictors of Mortality in Critically Ill COVID-19 Patients Demanding High Oxygen Flow: A Thin Line between Inflammation, Cytokine Storm, and Coagulopathy

Viseslav Popadic | Slobodan Klasnja | ... | Marija Zdravkovic
  • Special Issue
  • - Volume 2021
  • - Article ID 6617969
  • - Research Article

The Association of Polymorphisms in Nrf2 and Genes Involved in Redox Homeostasis in the Development and Progression of Clear Cell Renal Cell Carcinoma

Smiljana Mihailovic | Vesna Coric | ... | Marija Pljesa Ercegovac
  • Special Issue
  • - Volume 2021
  • - Article ID 6661940
  • - Research Article

Factorial Analysis of the Cardiometabolic Risk Influence on Redox Status Components in Adult Population

Aleksandra Klisic | Nebojsa Kavaric | ... | Ana Ninic
  • Special Issue
  • - Volume 2021
  • - Article ID 6615787
  • - Research Article

Predicting Severity and Intrahospital Mortality in COVID-19: The Place and Role of Oxidative Stress

Ivan Cekerevac | Tamara Nikolic Turnic | ... | Vladimir Jakovljevic
  • Special Issue
  • - Volume 2021
  • - Article ID 6676057
  • - Research Article

The Impact of Hepatitis C Virus Genotypes on Oxidative Stress Markers and Catalase Activity

Vukica Đorđević | Dobrila Stanković Đorđević | ... | Jana Pešić Stanković
  • Special Issue
  • - Volume 2021
  • - Article ID 6678924
  • - Research Article

GSTM1 Modulates Expression of Endothelial Adhesion Molecules in Uremic Milieu

Djurdja Jerotic | Sonja Suvakov | ... | Tatjana Simic
Oxidative Medicine and Cellular Longevity
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