Exercise is perhaps one of the most characteristic examples demonstrating that free radicals are not necessarily “harmful” entities, considering that the well-known benefits of regular exercise on muscle function and health are accompanied by repeated episodes of oxidative and nitrosative stress. Currently, the field of exercise redox biology is being rapidly expanded. Indeed, the significance of free radicals has been underlined by the emerging positive links between exercise-induced changes in cellular redox events and defense against many human diseases. In addition, an ongoing debate exists in the literature regarding the implications of antioxidant supplementation on physical performance and redox homeostasis.

We invite investigators to contribute original research articles as well as review articles that will stimulate the continuing efforts to understand the molecular, cellular, and physiological mechanisms through which exercise of all types may interfere with muscle and whole body redox biology and whether alterations in oxidative stress favors or disturbs the homeostatic function of an organism and for how long these effects might persist.

Considering that redox biology of exercise is by nature multidisciplinary, we are particularly interested in articles taking a holistic, transdisciplinary approach, which combines the various chemical, analytical, biochemical, nutritional, physiological, and medical aspects relevant to reactive species biology. Potential topics include, but are not limited to:

• Mechanisms through which exercise induces oxidative stress and inflammation during exercise
• Free radicals as signaling molecules for training adaptations
• Development and application of valid and reliable redox biomarkers in body fluids and tissues
• The impact of physical inactivity on redox biology of skeletal muscle and whole organisms
• Administration and timing of dietary antioxidants and nutraceuticals as modulators of redox homeostasis and physical performance
• Redox-mediated effects of exercise on health-related conditions and chronic diseases such as obesity, sarcopenia, rheumatoid arthritis, and diabetes

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