Ferroptosis is defined as an oxidative, iron-dependent form of cell death and characterized by the accumulation of reactive oxygen species (ROS) and lipid peroxidation products at lethal levels. Ferroptosis could be prevented by iron chelators and the aromatic amine ferrostatin-1.

Oxidative stress is thought to be involved in many cardiovascular diseases (e.g., myocardial ischemia reperfusion (I/R) injury, aortic dissection) and tumours. Recently, Fang et al. demonstrated that both iron chelation therapy and pharmacologically blocking ferroptosis could significantly alleviate long-term protection from cardiac I/R injury in mice. Their findings indicated that targeting ferroptosis may be a promising strategy for treating deadly heart disease. Moreover, many studies have revealed that ferroptosis plays a critical role in cancer development and treatment response, and many novel therapeutically strategies based on ferroptosis have been developed to fight against cancer. However, the epigenetic mechanisms regulating ferroptosis in cardiovascular diseases and tumours remain largely unknown.

This Special Issue will focus on the epigenetic mechanisms (including protein methylation, acetylation and ubiquitination, DNA methylation, RNA methylation, and other types of epigenetic modifications) regulating ferroptosis in the cardiovascular system and tumours. We encourage the submission of in vitro, in vivo, clinical studies and reviews describing how epigenetic mechanisms affect ferroptosis involved in cardiovascular diseases and tumours. We especially welcome studies that investigate epigenetic modification-related inhibitors for the treatment of related diseases.

Potential topics include but are not limited to the following:

• Novel therapeutic strategies targeting to epigenetic mechanisms for ferroptosis related diseases (in vitro and in vivo studies), especially cardiovascular diseases and/or tumours
• Protein post-translational modifications in ferroptosis and its related cardiovascular diseases and/or tumours
• DNA methylation in ferroptosis and its related cardiovascular diseases and/or tumours
• RNA methylation in ferroptosis and its related cardiovascular diseases and/or tumours