Oxidative Medicine and Cellular Longevity

Oxidative Stress in Age-Related Chronic Disease: From Bench to Bedside


Publishing date
01 Sep 2019
Status
Closed
Submission deadline
26 Apr 2019

1University of Genoa, Genova, Italy

2University of Genoa, Genoa, Italy

3Magna Graecia University of Catanzaro, Catanzaro, Italy

4University of Mississippi Medical Center, Jackson, USA

This issue is now closed for submissions.
More articles will be published in the near future.

Oxidative Stress in Age-Related Chronic Disease: From Bench to Bedside

This issue is now closed for submissions.
More articles will be published in the near future.

Description

Aging is an irreversible biological process that may be associated with an increased incidence of chronic diseases, involving different organs and systems. Western societies are facing the unprecedented aging of the population (silver tsunami); this increasing number of older people will also need tailored healthcare for largely chronic diseases.

The causes of aging remain largely unknown; however, the free radicals theory of aging still provides a strong conceptual framework for experimental and clinical evidence on aging.

Oxidative stress and ROS generation are important molecular mechanisms for the maintenance of homeostasis. Namely, the integrity of the intracellular mitochondrial activity and of the endogenous antioxidant enzymatic defense system plays a role in shaping the aging process, leading to cell damage. As a result, oxidative intracellular damage impacts all age-related chronic conditions and, on a cellular basis, it is intertwined with biological aging, cellular survival, and longevity as well as the onset and progression of several age-related diseases such as cardiovascular diseases, cancer, neurodegeneration, metabolism, immune function, hematological diseases, lung diseases, and kidney failure.

Despite substantial correlative evidence to support it, studies in the last years have raised doubts over its importance. In particular, the expected elevation in oxidative damage does not impact linearly on lifespan and on the progression and worsening of age-related clinical conditions. All these findings raise fundamental questions over whether the free-radical damage theory remains useful for understanding the aging process and variations in lifespan and life histories.

Growing evidence indicates a correlation between oxidative damage and frailty status, instead of the mere chronological age. Frailty is a biological syndrome characterized by higher comorbidity and disability, due to decreased biological homeostasis, which put elderly subjects at higher risk when facing minor environmental stressors.

Thus, the free radical theory of aging seems to apply to biological age rather than chronological age, driving premature aging and higher comorbidity burden.

Since a major task for medicine and for social care sciences in modern societies is to delay or even treat the onset of chronic diseases, disability, and frailty, it is of key importance to design treatments that can prevent or reverse oxidative damage.

The deeper understanding of the cellular and molecular mechanisms of oxidative stress and its factual role in the development of age-related diseases will provide potential ways to target them and turn bench-to-bedside research into clinical strategies.

In this special issue, we invite authors to submit original research as well as review articles that focus on the current understanding of oxidative stress in age-related chronic disease, with an emphasis on identification and validation of new targets and pathways for the prognostic and therapeutic application.

Potential topics include but are not limited to the following:

  • Therapeutic relevance of oxidative-stress targeting in aging and age-related diseases (Alzheimer’s disease and neurodegeneration; psychiatric, chronic clinical conditions including depression and bipolar disorders; osteoporosis; renal diseases and end-stage renal failure; cardiovascular diseases, including atherosclerosis and heart failure; diabetes and related microvascular and macrovascular complications)
  • Novel therapeutic targets in age-associated malignancies, including epigenetics (cancer and hematological malignancies)
  • Metabolic dysfunctions and frailty in age-related chronic diseases (sarcopenia and frailty; nutrition and biological aging)
  • Immunomodulation as an innovative approach to managing age-related chronic diseases

Articles

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  • - Article ID 6306104
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Erratum to “Antioxidant and Anti-Inflammatory Properties of Anthocyanins Extracted from Oryza sativa L. in Primary Dermal Fibroblasts”

Pakhawadee Palungwachira | Salunya Tancharoen | ... | Thamthiwat Nararatwanchai
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  • - Volume 2020
  • - Article ID 7901270
  • - Review Article

Central Role of Oxidative Stress in Age-Related Macular Degeneration: Evidence from a Review of the Molecular Mechanisms and Animal Models

Samuel Abokyi | Chi-Ho To | ... | Dennis Y. Tse
  • Special Issue
  • - Volume 2019
  • - Article ID 4598167
  • - Review Article

New Insights for Cellular and Molecular Mechanisms of Aging and Aging-Related Diseases: Herbal Medicine as Potential Therapeutic Approach

Yanfei Liu | Weiliang Weng | ... | Yue Liu
  • Special Issue
  • - Volume 2019
  • - Article ID 3940739
  • - Review Article

Interplay between the Adaptive Immune System and Insulin Resistance in Weight Loss Induced by Bariatric Surgery

José Romeo Villarreal-Calderón | Ricardo X. Cuéllar | ... | Gerardo García-Rivas
  • Special Issue
  • - Volume 2019
  • - Article ID 4764071
  • - Research Article

Pioglitazone Protects Compression-Mediated Apoptosis in Nucleus Pulposus Mesenchymal Stem Cells by Suppressing Oxidative Stress

Yiqiang Hu | Liang Huang | ... | Liming Xiong
  • Special Issue
  • - Volume 2019
  • - Article ID 4609702
  • - Review Article

Iron Redox Chemistry and Implications in the Parkinson’s Disease Brain

Dinendra L. Abeyawardhane | Heather R. Lucas
  • Special Issue
  • - Volume 2019
  • - Article ID 7495629
  • - Review Article

The Signaling of Cellular Senescence in Diabetic Nephropathy

Yabing Xiong | Lili Zhou
  • Special Issue
  • - Volume 2019
  • - Article ID 9073451
  • - Research Article

Nω-(Carboxymethyl)arginine Is One of the Dominant Advanced Glycation End Products in Glycated Collagens and Mouse Tissues

Sho Kinoshita | Katsumi Mera | ... | Ryoji Nagai
  • Special Issue
  • - Volume 2019
  • - Article ID 9874159
  • - Review Article

Nutrients in the Prevention of Alzheimer’s Disease

Anna Laura Cremonini | Irene Caffa | ... | Fiammetta Monacelli
  • Special Issue
  • - Volume 2019
  • - Article ID 3085756
  • - Review Article

Oxidative Stress and Advanced Lipoxidation and Glycation End Products (ALEs and AGEs) in Aging and Age-Related Diseases

Nurbubu T. Moldogazieva | Innokenty M. Mokhosoev | ... | Alexander A. Terentiev
Oxidative Medicine and Cellular Longevity
 Journal metrics
Acceptance rate48%
Submission to final decision56 days
Acceptance to publication37 days
CiteScore7.300
Impact Factor5.076
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