Oxidative Medicine and Cellular Longevity

Redox-Activated Signal Transduction Pathways Mediating Cellular Functions in Inflammation, Differentiation, Degeneration, Transformation, and Death


Status
Published

1IRCCS SDN, Naples, Italy

2University of Turku, Biocity, Turku, Finland

3Gifu Pharmaceutical University, Gifu, Japan


Redox-Activated Signal Transduction Pathways Mediating Cellular Functions in Inflammation, Differentiation, Degeneration, Transformation, and Death

Description

Reactive oxygen and nitrogen species (ROS and RNS) are needed for normal cellular functions. The unbalanced production of ROS and RNS is characteristic of abnormal cellular conditions where they may function as second messengers activating or inactivating cellular messaging networks. The effects of ROS and RNS can be mediated through tyrosine kinase receptors, receptor serine/threonine kinases, and cytoplasmic protein kinase signaling molecules. Functionally ROS and RNS participate in a large number of mechanisms ranging from inflammation related cellular responses, differentiation, migration, degeneration, transformation, and death to more specific phenomena, such as oncogene-induced senescence (OIS) and excitotoxicity mediated neuronal cell damage.

As ROS and RNS are needed for normal cellular functions and their effects depend on their localization and concentration, the direct targeting of ROS and RNS in pathological conditions to selectively prevent abnormal functions is challenging. Thus, elucidation of the signal transduction pathways and small molecules mediating ROS and RNS-induced redox imbalance could indicate druggable target molecules that then could be potentially used to enhance the effect of drugs in preclinical and clinical combination trials.

The scope of this special issue is to highlight ROS and RNS as signaling mediators and to describe signal transduction pathways mediating the effects of ROS and RNS in pathological conditions. We invite authors to submit both original research articles and review articles.

Potential topics include, but are not limited to:

  • Redox molecules in cell proliferation, cell differentiation, cell migration, cellular dysfunction, neurodegeneration, and inflammation related cellular response
  • ROS and RNS as signaling intermediates in cellular responses
  • Tyrosine kinase receptors, serine/threonine kinase receptors, and cytoplasmic protein kinase signaling molecules as mediators of redox signaling
  • Novel techniques to study ROS and RNS signaling intermediates and their interaction with tyrosine kinase receptors, serine/threonine kinase receptors, and cytoplasmic protein kinase signaling molecules
  • Preclinical studies on redox-related kinase inhibitors used alone or in combination with conventional drugs in the treatments of cancer, cardiovascular diseases, lung diseases, and neurodegeneration
  • Clinical studies reporting the use of antioxidants or related molecules and their relevance to signal transduction

Articles

  • Special Issue
  • - Volume 2016
  • - Article ID 8479718
  • - Editorial

Redox-Activated Signal Transduction Pathways Mediating Cellular Functions in Inflammation, Differentiation, Degeneration, Transformation, and Death

Tetsuro Kamiya | Michael Courtney | Mikko O. Laukkanen
  • Special Issue
  • - Volume 2016
  • - Article ID 7316492
  • - Review Article

Nrf2 and Notch Signaling in Lung Cancer: Near the Crossroad

Angelo Sparaneo | Federico Pio Fabrizio | Lucia Anna Muscarella
  • Special Issue
  • - Volume 2016
  • - Article ID 5829063
  • - Research Article

Identification of Redox and Glucose-Dependent Txnip Protein Interactions

Benjamin J. Forred | Skyla Neuharth | ... | Peter F. Vitiello
  • Special Issue
  • - Volume 2016
  • - Article ID 6235641
  • - Review Article

Redox Homeostasis and Cellular Antioxidant Systems: Crucial Players in Cancer Growth and Therapy

Barbara Marengo | Mariapaola Nitti | ... | Cinzia Domenicotti
  • Special Issue
  • - Volume 2016
  • - Article ID 2989076
  • - Review Article

Effects of Oxidative Stress on Mesenchymal Stem Cell Biology

Ryan A. Denu | Peiman Hematti
  • Special Issue
  • - Volume 2016
  • - Article ID 2746457
  • - Review Article

NRF2, a Key Regulator of Antioxidants with Two Faces towards Cancer

Jaieun Kim | Young-Sam Keum
  • Special Issue
  • - Volume 2016
  • - Article ID 3612589
  • - Review Article

Extracellular Superoxide Dismutase: Growth Promoter or Tumor Suppressor?

Mikko O. Laukkanen
  • Special Issue
  • - Volume 2016
  • - Article ID 3565127
  • - Review Article

ROS, Cell Senescence, and Novel Molecular Mechanisms in Aging and Age-Related Diseases

Pierpaola Davalli | Tijana Mitic | ... | Domenico D’Arca
  • Special Issue
  • - Volume 2016
  • - Article ID 1284372
  • - Research Article

Cross Talk Mechanism among EMT, ROS, and Histone Acetylation in Phorbol Ester-Treated Human Breast Cancer MCF-7 Cells

Tetsuro Kamiya | Aki Goto | ... | Tetsuo Adachi
  • Special Issue
  • - Volume 2016
  • - Article ID 6724585
  • - Research Article

Zinc Chelation Mediates the Lysosomal Disruption without Intracellular ROS Generation

Andreza Cândido Matias | Tânia Maria Manieri | Giselle Cerchiaro
Oxidative Medicine and Cellular Longevity
 Journal metrics
Acceptance rate48%
Submission to final decision56 days
Acceptance to publication37 days
CiteScore7.300
Impact Factor5.076
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