Stroke is one of the main causes of mortality and disability in most countries, causing much economic burden on patients and governments. The current best treatment plans for ischemic stroke include intravenous injection of plasminogen activator and endovascular thrombectomy for large vessel occlusion to improve clinical outcomes. However, only few patients receive these therapies as the therapeutic time window is very narrow after ischemic stroke attack. Therefore, there is an urgent need to find new therapeutic targets for ischemic stroke.

Studies have found that reactive oxygen species (ROS) have been implicated in brain injury induced by ischemic stroke. There is a rapid increase in the production of ROS immediately after acute ischemic stroke. This overwhelming antioxidant defence would cause further tissue damage. These ROS can damage cellular macromolecules leading to autophagy, apoptosis, and necrosis. However, current measures to protect the brain against severe stroke damage are insufficient. Thus, it is critical to investigate antioxidant strategies that lead to the diminution of oxidative injury.

The aim of this Special Issue is to collate any manuscripts related to the mechanisms involved in ROS generation, including the mitochondrial role in ROS generation, the role of oxidative stress in the pathogenesis of ischemic stroke, and the novel therapeutic strategies to be tested to reduce cerebral damage. Original research and review articles are welcome.

Potential topics include but are not limited to the following:

• Antioxidant strategies that alleviate oxidative injury after stroke
• Brain haemorrhage and oxidative stress
• Cell death mechanisms and oxidative stress in stroke
• Endoplasmic reticulum stress and oxidative stress in stroke
• Genetics of oxidative stress in stroke
• Global and neonatal brain injury and oxidative stress
• Mitochondrial role in ROS generation in stroke
• Neuroinflammation and oxidative stress in stroke
• Novel therapeutic strategies to reduce cerebral damage in stroke
• Oxidative stress and arteriosclerosis, lifestyle disease, and proteasome dysfunction in stroke
• Oxidative stress and vascular dementia
• Oxidative stress biomarkers in stroke
• Oxidative stress mechanisms in stroke
• Stem cells and oxidative stress in stroke
• Surgical treatment and oxidative stress in stroke