Oxidative Medicine and Cellular Longevity

Oxidative Stress and Inflammation Interaction in Ischemia Reperfusion Injury: Role of Programmed Cell Death 2020


Publishing date
01 Jan 2021
Status
Closed
Submission deadline
04 Sep 2020

Lead Editor

1The Third Affiliated Hospital of Sun Yat-sen University, Guangdong, China

2Sun Yat-sen University, Guangzhou, China

3Stanford University, California, USA

4Massachusetts Eye and Ear, Massachusetts, USA

5Massachusetts General Hospital, Massachusetts, USA

This issue is now closed for submissions.
More articles will be published in the near future.

Oxidative Stress and Inflammation Interaction in Ischemia Reperfusion Injury: Role of Programmed Cell Death 2020

This issue is now closed for submissions.
More articles will be published in the near future.

Description

Oxidative stress and inflammation are interactive and play critical roles in ischemia reperfusion injury in multiple organs. During prolonged ischemia, tissues are energetically deficient. When restoring blood flow, reperfusion not only introduces abrupt energy shift to tissues, but also paradoxically exacerbates tissue injury by inducing oxidative stress and inflammation. These molecular events can lead to different types of programmed cell death (e.g., apoptosis, autophagy, necroptosis, pyroptosis, and ferroptosis) depending on the stimulation (i.e., oxidative stress, or inflammation, or their combination). For example, oxidative stress can induce cell apoptosis and ferroptosis by increasing pro-apoptotic signal (e.g., increase of caspases 3) and lipid peroxidation; further, it can prompt cell necroptosis by enhancing necroptosis-related protein receptor-interacting protein kinase 3. On the other hand, inflammation can elevate proinflammatory cytokines and chemokines release inducing inflammasome-mediated cell pyroptosis. Each of these types of cell death can solely or jointly disrupt autophagy, resulting in ischemia reperfusion injury. However, the molecular mechanism(s) of the interaction of oxidative stress and inflammation, and their interplay with different types of programmed cell death in ischemia reperfusion injury is unclear.

The aim of this Special Issue is to collate original research articles as well as review articles that will stimulate the continuing efforts to understand these molecular mechanism(s). Knowledge on the interaction of oxidative stress and inflammation, and their interplay with programmed cell death (e.g., apoptosis, necroptosis, autophagy, pyroptosis, and ferroptosis etc.) in ischemia reperfusion injury under normal and diseased conditions will help to develop strategies in combating these pathological conditions.

Potential topics include but are not limited to the following:

  • Role and mechanism of the interaction of oxidative stress and inflammation in ischemia reperfusion injury in different organs (heart, lung, brain, liver, kidney, and/or intestine) under normal and diseased conditions (e.g., diabetes and aging)
  • Roles of different programmed cell death in organs ischemia reperfusion injury under normal and diseased conditions
  • Cellular protective interventions targeting programmed cell death (apoptosis, necroptosis, and autophagy) that contribute to cellular repairing during ischemia reperfusion injury
  • Recent advances in preventing ischemia-reperfusion injury with a focus on oxidative stress and inflammation-mediated programmed cell death

Articles

  • Special Issue
  • - Volume 2021
  • - Article ID 8839394
  • - Research Article

1-O-Hexyl-2,3,5-Trimethylhydroquinone Ameliorates the Development of Preeclampsia through Suppression of Oxidative Stress and Endothelial Cell Apoptosis

Lai Jiang | Yanping Gong | ... | Yuyan Ma
  • Special Issue
  • - Volume 2020
  • - Article ID 8815349
  • - Review Article

Pharmacological Modulation of Cardiac Remodeling after Myocardial Infarction

Wei Zhao | Jia Zhao | Jianhui Rong
  • Special Issue
  • - Volume 2020
  • - Article ID 9782062
  • - Research Article

Neuroprotection Effect of Astragaloside IV from 2-DG-Induced Endoplasmic Reticulum Stress

Yu Fu | Jianhang Cai | ... | Yonggui He
  • Special Issue
  • - Volume 2020
  • - Article ID 2616871
  • - Research Article

Involvement of the miR-137-3p/CAPN-2 Interaction in Ischemia-Reperfusion-Induced Neuronal Apoptosis through Modulation of p35 Cleavage and Subsequent Caspase-8 Overactivation

He Wang | Qian Yu | ... | Xiao-Qian Li
  • Special Issue
  • - Volume 2020
  • - Article ID 4546851
  • - Research Article

A Preclinical Systematic Review of Curcumin for Protecting the Kidney with Ischemia Reperfusion Injury

Zi-Hao Wang | Li-Hui Deng | ... | Qun Zheng
  • Special Issue
  • - Volume 2020
  • - Article ID 5394096
  • - Review Article

Implication of Gut Microbiota in Cardiovascular Diseases

Wenyi Zhou | Yiyu Cheng | ... | Mingyi Zhao
  • Special Issue
  • - Volume 2020
  • - Article ID 8638301
  • - Research Article

Dexmedetomidine Improves Lung Function by Promoting Inflammation Resolution in Patients Undergoing Totally Thoracoscopic Cardiac Surgery

Junji Cui | Mintai Gao | ... | Qingshi Zeng
  • Special Issue
  • - Volume 2020
  • - Article ID 7413693
  • - Research Article

MG53 Protects against Sepsis-Induced Myocardial Dysfunction by Upregulating Peroxisome Proliferator-Activated Receptor-α

Xue Han | Daili Chen | ... | Minghui Cao
  • Special Issue
  • - Volume 2020
  • - Article ID 9187406
  • - Research Article

Electroacupuncture Pretreatment Attenuates Intestinal Injury after Autogenous Orthotopic Liver Transplantation in Rats via the JAK/STAT Pathway

Lili Jia | Wenli Yu | ... | Yiqi Weng
  • Special Issue
  • - Volume 2020
  • - Article ID 7913418
  • - Research Article

MiR-181c-5p Promotes Inflammatory Response during Hypoxia/Reoxygenation Injury by Downregulating Protein Tyrosine Phosphatase Nonreceptor Type 4 in H9C2 Cardiomyocytes

Sheng Wang | Liang Ge | ... | Zhengyuan Xia
Oxidative Medicine and Cellular Longevity
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Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.