Oxidative Medicine and Cellular Longevity

Molecular Basis of the Inflammation Related to Obesity

Publishing date
01 Nov 2018
Submission deadline
22 Jun 2018

1University of Navarra, Navarra, Spain

2University College London, London, UK

3Santiago de Compostela University, Santiago de Compostela, Spain

4University of Chile, Santiago de Chile, Chile

5Pomeranian Medical University, Szczecin, Poland

Molecular Basis of the Inflammation Related to Obesity


Obesity, considered as the epidemic of the XXI century, is a multifactorial and complex disease of which worldwide prevalence is still increasing in spite of the fact that some of the best groups of researchers started studying it more than half a century ago.

This pathological condition consists of an excessive fat accumulation together with a mild chronic inflammation. This accompanying proinflammatory status is considered the link between obesity and the development of its related comorbidities such as insulin resistance and type 2 diabetes, cardiovascular diseases, cancer, and nonalcoholic fatty liver disease.

In this sense, gathering the new advances in cells, animals or, preferentially, humans and trying to shed some light to further understand the molecular mechanisms involved in the initiation and maintenance of the inflammatory process are of great value for the scientific community. The main triggers have been considered hypoxia, oxidative stress, and endoplasmic reticulum stress, but this special issue seeks to find new information about these factors and would also welcome comprehensive reviews about one or several factors.

Potential topics include but are not limited to the following:

  • Metabolic imprinting
  • Browning and beiging processes
  • Regional and quantity of fat accumulation
  • Nutrigenetics and Nutrigenomics
  • Oxygen tension: including hypoxia and hyperoxia
  • Endoplasmic reticulum stress
  • Reactive oxygen species overproduction (oxidative stress) and antioxidants
  • Endocrine or immune control: hormones and adipokines, myokines, cytokines, and others
  • Macrophage infiltration and M1/M2 phenotype polarization
  • Omega 3, lipid mediators, and other fatty acids
  • Chrononutrition


  • Special Issue
  • - Volume 2019
  • - Article ID 5250816
  • - Editorial

Molecular Basis of the Inflammation Related to Obesity

Ana B. Crujeiras | Paul Cordero | ... | Pedro González-Muniesa
  • Special Issue
  • - Volume 2019
  • - Article ID 2695289
  • - Research Article

Cerium Oxide Nanoparticles Regulate Insulin Sensitivity and Oxidative Markers in 3T3-L1 Adipocytes and C2C12 Myotubes

Amaya Lopez-Pascual | Andoni Urrutia-Sarratea | ... | Pedro González-Muniesa
  • Special Issue
  • - Volume 2018
  • - Article ID 6256052
  • - Research Article

Oxidative Stress Induced by Excess of Adiposity Is Related to a Downregulation of Hepatic SIRT6 Expression in Obese Individuals

Marcos C. Carreira | Andrea G. Izquierdo | ... | Ana B. Crujeiras
  • Special Issue
  • - Volume 2018
  • - Article ID 6598326
  • - Research Article

Oxidative Stress in Cardiac Tissue of Patients Undergoing Coronary Artery Bypass Graft Surgery: The Effects of Overweight and Obesity

Yves Gramlich | Andreas Daiber | ... | Ulrich Hink
  • Special Issue
  • - Volume 2018
  • - Article ID 5407482
  • - Research Article

Curcumin Modulates DNA Methyltransferase Functions in a Cellular Model of Diabetic Retinopathy

Andrea Maugeri | Maria Grazia Mazzone | ... | Antonella Agodi
  • Special Issue
  • - Volume 2018
  • - Article ID 2151429
  • - Research Article

Changes of Plasma FABP4, CRP, Leptin, and Chemerin Levels in relation to Different Dietary Patterns and Duodenal-Jejunal Omega Switch Surgery in Sprague–Dawley Rats

Dominika Stygar | Elżbieta Chełmecka | ... | Konrad Wojciech Karcz
Oxidative Medicine and Cellular Longevity
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