Oxidative Medicine and Cellular Longevity

Effect of Nutraceuticals and Pharmaceuticals on Oxidative Stress in Vascular Aging and Cardiovascular Disease


Publishing date
01 Oct 2019
Status
Closed
Submission deadline
31 May 2019

Lead Editor

1IRCCS Neuromed, Pozzilli, Italy

2University of Texas Southwestern Medical Center, Texas, USA

3ICAHN School of Medicine, New York, USA

This issue is now closed for submissions.
More articles will be published in the near future.

Effect of Nutraceuticals and Pharmaceuticals on Oxidative Stress in Vascular Aging and Cardiovascular Disease

This issue is now closed for submissions.
More articles will be published in the near future.

Description

Aging represents one of the most potent independent predictors of future cardiovascular events. Increased arterial stiffness, impaired vascular endothelial function, and impairment of oxidative balance are the most important clinical events that occur with age, both in humans and in animals, contributing to the development of hypertension, left ventricular remodeling, coronary artery diseases, atherosclerotic vascular diseases, congestive heart failure, and cardiovascular events such as myocardial infarction. These processes, due in large part to a reduction in endothelium-derived nitric oxide bioavailability, increased production of vasoconstrictors, increased reactive oxygen species (ROS), and a dysregulation of several intracellular pathways, have been significantly reduced by a range of pharmacological approaches. Although many drugs are effective, the molecular mechanisms and long-term side effects are still unknown and are currently an area of active research. In the last decade, an increasing number of natural compounds have been shown to be efficacious in preventative medicine or in the treatment of cardiovascular disease (CVD). An increasing number of studies have highlighted the protective effects of nutraceuticals on the cardiovascular system, but the molecular signaling remains to be elucidated.

Consistent with this idea, we invite investigators to contribute original research as well as review articles on nutraceuticals as well as pharmaceuticals able to treat or prevent the development of CVD through the modulation of oxidative stress-dependent signalling pathways. The contributions should be focused on new mechanisms, new molecules, and new approaches to reduce cardiovascular risk.

Potential topics include but are not limited to the following:

  • In vitro and in vivo studies on the role of oxidative stress in vascular aging: nutraceuticals and drugs, care, and prevention
  • Nutraceuticals and pharmaceuticals able to modulate oxidative stress and antioxidant machinery in aging and CVD
  • Nutraceuticals and drugs in CVD: free radicals and oxidative damage, imbalance of endothelium‐derived nitric oxide bioavailability, and vasoconstrictors/vasodilators
  • Inflammation, oxidative stress, and CVD: novel mechanisms and therapeutic strategies
  • ROS imbalance in aging and CVD: new protective mechanisms of action of natural compounds and drugs
  • Nutraceuticals and drugs: what is the best to treat and prevent CVD and vascular aging?

Articles

  • Special Issue
  • - Volume 2020
  • - Article ID 2176728
  • - Review Article

Cardioprotective Effects of Dietary Phytochemicals on Oxidative Stress in Heart Failure by a Sex-Gender-Oriented Point of View

Klara Komici | Valeria Conti | ... | Graziamaria Corbi
  • Special Issue
  • - Volume 2019
  • - Article ID 6304058
  • - Research Article

Myricetin Alleviates Pathological Cardiac Hypertrophy via TRAF6/TAK1/MAPK and Nrf2 Signaling Pathway

Hai-han Liao | Nan Zhang | ... | Qi-zhu Tang
  • Special Issue
  • - Volume 2019
  • - Article ID 7049237
  • - Research Article

Cardiac Rehabilitation Increases SIRT1 Activity and β-Hydroxybutyrate Levels and Decreases Oxidative Stress in Patients with HF with Preserved Ejection Fraction

Graziamaria Corbi | Valeria Conti | ... | Amelia Filippelli
  • Special Issue
  • - Volume 2019
  • - Article ID 1616239
  • - Research Article

β-Lactoglobulin Heptapeptide Reduces Oxidative Stress in Intestinal Epithelial Cells and Angiotensin II-Induced Vasoconstriction on Mouse Mesenteric Arteries by Induction of Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) Translocation

Giacomo Pepe | Manuela Giovanna Basilicata | ... | Pietro Campiglia
  • Special Issue
  • - Volume 2019
  • - Article ID 7838149
  • - Research Article

Supplementation with Spirulina platensis Modulates Aortic Vascular Reactivity through Nitric Oxide and Antioxidant Activity

Aline de Freitas Brito | Alexandre Sérgio Silva | ... | Bagnólia Araújo Silva
  • Special Issue
  • - Volume 2019
  • - Article ID 8742075
  • - Research Article

Evaluation of the Effect Derived from Silybin with Vitamin D and Vitamin E Administration on Clinical, Metabolic, Endothelial Dysfunction, Oxidative Stress Parameters, and Serological Worsening Markers in Nonalcoholic Fatty Liver Disease Patients

Alessandro Federico | Marcello Dallio | ... | Carmelina Loguercio
  • Special Issue
  • - Volume 2019
  • - Article ID 2650429
  • - Review Article

Circulating Leukocytes and Oxidative Stress in Cardiovascular Diseases: A State of the Art

Speranza Rubattu | Maurizio Forte | Salvatore Raffa
  • Special Issue
  • - Volume 2019
  • - Article ID 2580409
  • - Research Article

Danshenol A Alleviates Hypertension-Induced Cardiac Remodeling by Ameliorating Mitochondrial Dysfunction and Suppressing Reactive Oxygen Species Production

Kai Chen | Yiqing Guan | ... | Guohua Zhang
  • Special Issue
  • - Volume 2019
  • - Article ID 1202676
  • - Research Article

Malaysian Tualang Honey Inhibits Hydrogen Peroxide-Induced Endothelial Hyperpermeability

Kogilavanee Devasvaran | Jun Jie Tan | ... | Yoke Keong Yong
  • Special Issue
  • - Volume 2019
  • - Article ID 2567198
  • - Research Article

Moringa oleifera Seeds Improve Aging-Related Endothelial Dysfunction in Wistar Rats

Joseph Iharinjaka Randriamboavonjy | Sandrine Heurtebise | ... | Angela Tesse
Oxidative Medicine and Cellular Longevity
 Journal metrics
Acceptance rate49%
Submission to final decision76 days
Acceptance to publication38 days
CiteScore4.520
Impact Factor4.868
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