Oxidative Medicine and Cellular Longevity

mTOR Signaling in Cardiometabolic Disease, Cancer, and Aging 2018


Status
Published

Lead Editor

1Virginia Commonwealth University, Richmond, USA

2University of Coimbra, Coimbra, Portugal

3University of Nebraska Medical Center, Omaha, USA


mTOR Signaling in Cardiometabolic Disease, Cancer, and Aging 2018

Description

The mammalian target of rapamycin (mTOR), an evolutionarily conserved serine/threonine kinase, plays a significant role in integrating cellular and environmental cues that modulate cell metabolism, growth, proliferation, survival, and homeostasis. Distinct roles of mTOR were identified in gene transcription, protein synthesis, tissue regeneration and repair, oxidative stress, immunity, aging, and cell death which include autophagy and apoptosis. Emerging evidence over the last decade indicates that deregulation of mTOR signaling has been implicated in many human diseases, including cancer, obesity, diabetic complications, pulmonary hypertension, cardiovascular diseases, and neurodegeneration. Moreover, oxidative stress has also been etiologically implicated in these wide varieties of disease processes and states. Notably, the mTOR pathway is activated during various cellular processes including tumor formation and angiogenesis, insulin resistance, adipogenesis, and T-lymphocyte activation. Based on its pathophysiological importance, the mTOR signaling pathway has attracted broad scientific and clinical interest as a potential therapeutic target to treat a variety of diseases associated with oxidative stress, aging, proliferative disorders, and metabolic abnormalities.

We invite investigators to contribute original research articles as well as review articles that will advance our understanding of the mTOR signaling pathways in metabolic as well as neurodegenerative diseases, cancer, and aging, which could be pivotal for the development of novel therapeutic strategies to treat many human diseases.

Potential topics include but are not limited to the following:

  • Regulation of cellular growth, proliferation, and survival by mTOR
  • mTOR signaling in diabetes and its vascular complications
  • Cardiovascular disease and mTOR pathway
  • mTOR signaling in other metabolic disorders
  • Regulation of immune system by mTOR
  • mTOR signaling in cancer and therapeutic options with mTOR inhibitors
  • Involvement of mTOR signaling in neurodegenerative disease
  • The role of mTOR signaling in longevity and aging

Articles

  • Special Issue
  • - Volume 2019
  • - Article ID 9692528
  • - Editorial

mTOR Signaling in Cardiometabolic Disease, Cancer, and Aging 2018

Anindita Das | Flávio Reis | Paras Kumar Mishra
  • Special Issue
  • - Volume 2018
  • - Article ID 8364608
  • - Research Article

Comparison of Cardiac miRNA Transcriptomes Induced by Diabetes and Rapamycin Treatment and Identification of a Rapamycin-Associated Cardiac MicroRNA Signature

Anthony M. Belenchia | Madhavi P. Gavini | ... | Lakshmi Pulakat
  • Special Issue
  • - Volume 2018
  • - Article ID 3693625
  • - Review Article

Therapeutic Use of mTOR Inhibitors in Renal Diseases: Advances, Drawbacks, and Challenges

Sofia D. Viana | Flávio Reis | Rui Alves
  • Special Issue
  • - Volume 2018
  • - Article ID 5073420
  • - Research Article

Enhancing TFEB-Mediated Cellular Degradation Pathways by the mTORC1 Inhibitor Quercetin

Yi Huang | Yan Chen | ... | Jiyang Cai
  • Special Issue
  • - Volume 2018
  • - Article ID 9480316
  • - Research Article

Gankyrin Drives Malignant Transformation of Gastric Cancer and Alleviates Oxidative Stress via mTORC1 Activation

Bo Huang | Weiyang Cai | ... | Yanjie Zhang
  • Special Issue
  • - Volume 2018
  • - Article ID 5896786
  • - Review Article

New Insights into the Role of Exercise in Inhibiting mTOR Signaling in Triple-Negative Breast Cancer

Deborah Agostini | Valentina Natalucci | ... | Elena Barbieri
  • Special Issue
  • - Volume 2018
  • - Article ID 6141902
  • - Review Article

Emerging Role of mTOR Signaling-Related miRNAs in Cardiovascular Diseases

Arun Samidurai | Rakesh C. Kukreja | Anindita Das
  • Special Issue
  • - Volume 2018
  • - Article ID 6043064
  • - Research Article

Secreted Frizzled-Related Protein-2 Inhibits Doxorubicin-Induced Apoptosis Mediated through the Akt-mTOR Pathway in Soleus Muscle

Hilda Merino | Dinender K. Singla
  • Special Issue
  • - Volume 2018
  • - Article ID 1495170
  • - Research Article

Implication of the PI3K/Akt/mTOR Pathway in the Process of Incompetent Valves in Patients with Chronic Venous Insufficiency and the Relationship with Aging

Miguel A. Ortega | Ángel Asúnsolo | ... | Natalio García-Honduvilla
  • Special Issue
  • - Volume 2018
  • - Article ID 2798070
  • - Research Article

Mitofusin2 Induces Cell Autophagy of Pancreatic Cancer through Inhibiting the PI3K/Akt/mTOR Signaling Pathway

Ran Xue | Qinghua Meng | ... | Jianyu Hao
Oxidative Medicine and Cellular Longevity
 Journal metrics
Acceptance rate48%
Submission to final decision56 days
Acceptance to publication37 days
CiteScore7.300
Impact Factor5.076
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