Endogenous redox signaling molecules such as reactive oxygen species (ROS), nitric oxide (NO^•), and hydrogen sulfide (H₂S) have been widely reported to be involved in modulating cardiovascular activity under normal physiological conditions. Additionally, growing evidence from basic and clinical studies also suggests a probable role of redox imbalance as a potential causal mechanism in many cardiovascular diseases such as aging, heart failure, hypertension, and peripheral arterial disease. Elucidation of these mechanisms has led to the development of successful therapies, novel tools to characterize these clinical conditions, and enhancement of patient care.

We invite authors to submit original research and review articles that support the continuing efforts to 1) identify novel redox signaling pathways underlying cardiovascular diseases and 2) discover original therapeutic strategies to treat these conditions and the evaluation of outcomes. We are particularly interested in articles clarifying how redox molecules are involved in neural reflex control of cardiovascular activity under physiological and pathological conditions. Another particular interest of this issue will be focused on a role of redox signaling in mediating cardiovascular adaption to acute and long term exercise both in health and disease.

Potential topics include, but are not limited to:

• Redox biology in the autonomic nervous system in health and cardiovascular diseases
• Central nervous system redox signaling and abnormal cardiovascular reflexes in cardiovascular diseases such as heart failure, hypertension, aging, and peripheral arterial diseases
• Redox signaling and peripheral afferent sensitization/desensitization
• Redox signaling and ion channel dysfunction in central and peripheral nervous system
• Redox signaling and cardiovascular adaption to acute and/or long-term exercise in cardiovascular diseases
• Redox signaling and cardiac remodeling in cardiomyopathy, hypertension, and heart failure
• Redox signaling in the immune system in cardiovascular diseases such as heart failure, hypertension, aging, and peripheral arterial diseases
• Redox mechanisms involved with central, peripheral, and/or autonomic nervous system regulation of the immune system in health and cardiovascular disease
• Functional and redox changes in the immune system as a result of acute and/or long-term exercise in health and cardiovascular diseases
• Antioxidant therapy and autonomic dysfunction in cardiovascular diseases
• New and/or emerging therapies to treat abnormal redox signaling in cardiovascular disease