Oxidative Medicine and Cellular Longevity

Role of ROS-Induced NLRP3 Inflammasome Activation in Chronic Diseases and Conditions


Publishing date
01 Oct 2022
Status
Closed
Submission deadline
03 Jun 2022

Lead Editor

1Hubei University of Medicine, Shiyan, China

2Hubei University of Arts and Science , Xiangyang, China

3Huazhong University of Science and Technology , Wuhan, China

4University of Bologna, Bologna, Italy

This issue is now closed for submissions.
More articles will be published in the near future.

Role of ROS-Induced NLRP3 Inflammasome Activation in Chronic Diseases and Conditions

This issue is now closed for submissions.
More articles will be published in the near future.

Description

The incidence of chronic diseases (CDs), including type 2 diabetes, cardiovascular disease, and obesity, has increased over the last few decades. CDs are the leading cause of death and disability worldwide.

At the molecular level, overactivation of the NLRP3 inflammasome, a multi-protein complex consisting of NLRP3, ASC, and caspase-1, has been linked to the development of many CDs. The NLRP3 inflammasome can be activated by high glucose, palmitate, cholesterol crystals, ceramide, C-reactive protein, and islet amyloid polypeptide under damage-associated molecular patterns (DAMPs), resulting in caspase-1 cleavage and production of mature IL-1β. IL-1β-induced chronic inflammation may result in damage to the host and eventually lead to the development of CDs. Specifically, DAMPs induce the overproduction of ROS, leading to thioredoxin (TRX)-interacting protein (TXNIP) to dissociate from TRX and activation of the NLRP3 inflammasome. Accumulating evidence has suggested that ROS-generating mitochondria lead to spontaneous NLRP3 inflammasome activation, exacerbating inflammatory responses through multiple downstream events, such as an impairing insulin signal transduction associated with insulin resistance. Targeting the aberrant activation of the NLRP3 inflammasome induced by ROS under DAMPs represents an emerging therapeutic target for CDs.

The aim of this Special Issue is to collate original research and review articles describing advances in this field.

Potential topics include but are not limited to the following:

  • The role of ROS-induced NLRP3 inflammasome activation in the pathophysiological processes of CDs, such as type 2 diabetes and cardiovascular disease
  • Molecular mechanism of the NLRP3 inflammasome activation under DAMPs
  • Interplay between ROS, NLRP3 inflammasome, and metabolic diseases
  • Effect of bioactive compounds and nutrients on pathologies correlated with oxidative stress and NLRP3 inflammasome
  • Effect of natural compounds on pathologies related to oxidative stress and NLRP3 inflammasome
  • New experimental models for evaluation of oxidative stress and the NLRP3 inflammasome activation

Articles

  • Special Issue
  • - Volume 2022
  • - Article ID 9687925
  • - Review Article

Relevance of NLRP3 Inflammasome-Related Pathways in the Pathology of Diabetic Wound Healing and Possible Therapeutic Targets

Youjun Ding | Xiaofeng Ding | ... | Qian Tan
  • Special Issue
  • - Volume 2022
  • - Article ID 3711371
  • - Research Article

Dietary Fatty Acid Regulation of the NLRP3 Inflammasome via the TLR4/NF-κB Signaling Pathway Affects Chondrocyte Pyroptosis

Xin Jin | Xin Dong | ... | Hailun Gu
  • Special Issue
  • - Volume 2022
  • - Article ID 4608914
  • - Research Article

Attenuation of ROS/Chloride Efflux-Mediated NLRP3 Inflammasome Activation Contributes to Alleviation of Diabetic Cardiomyopathy in Rats after Sleeve Gastrectomy

Songhan Li | Shuohui Dong | ... | Sanyuan Hu
  • Special Issue
  • - Volume 2022
  • - Article ID 5631099
  • - Research Article

Renal and Inflammatory Proteins as Biomarkers of Diabetic Kidney Disease and Lupus Nephritis

Nathan H. Johnson | Robert W. Keane | Juan Pablo de Rivero Vaccari
  • Special Issue
  • - Volume 2021
  • - Article ID 1806344
  • - Research Article

Metformin Corrects Glucose Metabolism Reprogramming and NLRP3 Inflammasome-Induced Pyroptosis via Inhibiting the TLR4/NF-κB/PFKFB3 Signaling in Trophoblasts: Implication for a Potential Therapy of Preeclampsia

Yang Zhang | Weifang Liu | ... | Li Zou
  • Special Issue
  • - Volume 2021
  • - Article ID 7914829
  • - Research Article

ASC Speck Formation after Inflammasome Activation in Primary Human Keratinocytes

Nikola Smatlik | Stefan Karl Drexler | ... | Amir Sadegh Yazdi
Oxidative Medicine and Cellular Longevity
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Article of the Year Award: Outstanding research contributions of 2021, as selected by our Chief Editors. Read the winning articles.