Oxidative Medicine and Cellular Longevity

Antioxidant Therapies for Neurodegenerative Diseases: Mechanisms, Current Trends and Perspectives


Publishing date
03 Aug 2012
Status
Published
Submission deadline
03 Feb 2012

1Center for Oxidative Stress Research, Department of Biochemistry, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil

2Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada

3Experimental & Translational Respiratory Group, The University of Newcastle, Newcastle, NSW 2300, Australia

4Centro de Investigaciones Biomédicas en Radicales Libres, Facultad de Medicine, Universidad de la República Uruguay, Montevideo, Uruguay


Antioxidant Therapies for Neurodegenerative Diseases: Mechanisms, Current Trends and Perspectives

Description

The biomedical literature widely implicates free radicals and oxidative stress in the pathogenesis and development of neurodegenerative conditions such as Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and Huntington's disease, among others. As a result, an increasing number of researchers have been studying the effects of antioxidants in the central nervous system in order to develop new therapies to treat these conditions. However, although neuroprotective effects by antioxidants have been observed in vitro and in animal models, efficacy of antioxidant-based therapies in clinic has been revealed rare or inexistent. The reasons for this paradox are unknown but certainly rely on the diversity and complexity of the cellular mechanisms affected by antioxidants in both redox-dependent and -independent fashions.

We invite authors to submit their original research as well as review articles on the mechanistic effectiveness of antioxidants whose use has been suggested/established in prophylactic or therapeutic solutions to treat/prevent neurodegenerative disorders. We are interested in works exploring the actions of antioxidants in the central nervous system, focusing at cellular and molecular mechanisms. Besides, the mechanisms underlying deleterious side effects, drawbacks, or lack of effectiveness when transposing experimental procedures to the clinics are encouraged to be discussed. Articles that describe cellular mechanisms of action of new antioxidants as well as papers relating to the effectiveness of experimental therapies in animal models are also welcome. Potential topics include, but are not limited to:

  • Redox modulation of protein kinases and transcription factors related to neuron survival, cell cycle activation, and neuron plasticity
  • Antioxidant interference on balance between the different antioxidant enzymes
  • Polyphenols, terpenoids, and newly discovered natural compounds with potential antioxidant action on the central nervous system
  • Bioavailability of antioxidants: comparisons between diet, supplementation, and pharmacological administration
  • Antioxidants as alternatives to suppress the proinflammatory component of neurodegenerative diseases
  • Double-edged sword: oxidative stress induced by antioxidants
  • The role and mechanisms of glial cells on the maintenance of the redox balance in the brain
  • Reviews on effectiveness and perspectives of the use of antioxidants in clinic

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/oximed/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2012
  • - Article ID 895153
  • - Editorial

Antioxidant Therapies for Neurodegenerative Diseases: Mechanisms, Current Trends, and Perspectives

Daniel Pens Gelain | Guilherme Antonio Behr | ... | Madia Trujillo
  • Special Issue
  • - Volume 2012
  • - Article ID 472932
  • - Review Article

Antioxidant Therapies for Alzheimer's Disease

Ye Feng | Xiaochuan Wang
  • Special Issue
  • - Volume 2012
  • - Article ID 324256
  • - Review Article

Therapeutic Approach to Neurodegenerative Diseases by Medical Gases: Focusing on Redox Signaling and Related Antioxidant Enzymes

Kyota Fujita | Megumi Yamafuji | ... | Mami Noda
  • Special Issue
  • - Volume 2012
  • - Article ID 240146
  • - Review Article

Recent Advances in the Treatment of Neurodegenerative Diseases Based on GSH Delivery Systems

Ivana Cacciatore | Leonardo Baldassarre | ... | Francesco Pinnen
  • Special Issue
  • - Volume 2012
  • - Article ID 609421
  • - Review Article

Preclinical and Clinical Evidence of Antioxidant Effects of Antidepressant Agents: Implications for the Pathophysiology of Major Depressive Disorder

Guilherme A. Behr | José C. F. Moreira | Benicio N. Frey
  • Special Issue
  • - Volume 2012
  • - Article ID 907162
  • - Review Article

The Antioxidant Mechanisms Underlying the Aged Garlic Extract- and S-Allylcysteine-Induced Protection

Ana L. Colín-González | Ricardo A. Santana | ... | Perla D. Maldonado
  • Special Issue
  • - Volume 2012
  • - Article ID 843649
  • - Research Article

Accumulation of Exogenous Amyloid-Beta Peptide in Hippocampal Mitochondria Causes Their Dysfunction: A Protective Role for Melatonin

Sergio Rosales-Corral | Dario Acuna-Castroviejo | ... | Russel J. Reiter
  • Special Issue
  • - Volume 2012
  • - Article ID 750963
  • - Research Article

Antiaging Effect of Pine Pollen in Human Diploid Fibroblasts and in a Mouse Model Induced by D-Galactose

Gen-Xiang Mao | Ling-Di Zheng | ... | Jing Yan
  • Special Issue
  • - Volume 2012
  • - Article ID 820285
  • - Research Article

Heterogeneous Responses to Antioxidants in Noradrenergic Neurons of the Locus Coeruleus Indicate Differing Susceptibility to Free Radical Content

Ramatis B. de Oliveira | Fernanda S. Gravina | ... | Dirk F. van Helden
Oxidative Medicine and Cellular Longevity
 Journal metrics
Acceptance rate48%
Submission to final decision56 days
Acceptance to publication37 days
CiteScore7.300
Impact Factor5.076
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