Chronic inflammatory diseases constitute a burden to the majority of health systems all around the world, essentially due to the lack of safe, effective and affordable therapies. Diabetes, cardiovascular diseases, arthritis and joint diseases, allergies, and chronic obstructive pulmonary diseases are classified by the World Health Organization as specific chronic inflammation-mediated diseases. The processes underlying these diseases are multiple, but oxidative stress is undoubtedly involved in their pathogenesis, and in the development and establishment of a sustained inflammatory state.

Oxidative stress involves the overproduction of deleterious oxidant reactive species, but also the activation of a variety of pro-inflammatory signaling pathways that results in the production of a series of cytokines and chemokines, eicosanoids, growth factors, and cell cycle regulatory molecules, among others. This Annual Issue intends to gather original research and review articles that help to elucidate the role of oxidative stress and its resultant inflammatory mediators in the pathophysiology of chronic inflammation-mediated diseases, and the possible impact of this knowledge in the development of effective therapies. We encourage the submission of in vitro (biochemical or cellular) or in vivo studies on diabetes, cardiovascular diseases, arthritis and joint diseases, allergies, gastrointestinal diseases and chronic obstructive pulmonary diseases.

Potential topics include but are not limited to the following:

• General role of oxidative stress in the inflammatory process
• Production and detection of reactive species in inflammatory diseases
• Expression/production/modulation of inflammatory mediators triggered by reactive pro-oxidant species
• Strategies to prevent/treat oxidative stress-related inflammatory diseases
• Structure activity relationships (SAR) of antioxidant/anti-inflammatory compounds