Oxidative Medicine and Cellular Longevity

Oxidative Stress and Tissue Repair: Mechanism, Biomarkers, and Therapeutics


Publishing date
01 Dec 2019
Status
Closed
Submission deadline
26 Jul 2019

1Federal University of Viçosa, Viçosa, Brazil

2State University of Rio de Janeiro, Rio de Janeiro, Brazil

3Freie Universitat Berlin, Berlin, Germany

This issue is now closed for submissions.
More articles will be published in the near future.

Oxidative Stress and Tissue Repair: Mechanism, Biomarkers, and Therapeutics

This issue is now closed for submissions.
More articles will be published in the near future.

Description

Tissue repair is a complex process that occurs after tissue damage and usually involves three stages: inflammation, proliferation, and remodeling. In each of these stages, different cells migrate to the wound area in order to provide protection and mediate the expression of pro- and anti-inflammatory proteins. Neutrophils are the first cells to arrive in the injured area, sending redox signals, histamine, bradykinin, and thrombin that increases vascular permeability and promotes the migration of macrophages that mediate the expression of cytokines, growth factors, reactive oxygen species (ROS), and reactive nitrogen species (RNS). These ROS and RNS generated during inflammation can lead to cell membrane disorganization and protein oxidation by altering the cellular function. Therefore, the balance between ROS production and antioxidant defenses is important for efficient tissue repair in organs such as skin, liver, lungs, kidneys, heart, and testes. An increased oxygen consumption occurs during the process of tissue repair, resulting in an intense production of ROS and RNS. When the tissue is damaged by reactive species, it is common to observe lipid, protein, and DNA damage, leading to oxidative stress that impairs tissue repair.

Regarding the pivotal role played by antioxidant defenses in maintaining the morphological and functional integrity during tissue repair, the development of new drugs with antioxidant properties has been shown to be potentially useful in accelerating tissue recovery. These new drugs act by increasing enzymatic and nonenzymatic antioxidant defenses, protecting against ROS and RNS and attenuating the formation of biomarkers such as malondialdehyde, hydroperoxides, nitric oxide, and carbonyl protein at tissue level. This antioxidant activity might favor tissue repair, thus contributing to tissue protection and accelerating the healing process. In addition, treatments that increase levels of antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), and gluthatione-peroxidase (GPx) are shown to accelerate the healing process in different tissues. In this process, antioxidant molecules are potentially beneficial as they stimulate fibroblast migration and proliferation and increase collagen synthesis and scar tensile strength, a process partially mediated by ROS and RNS catalysis.

Accordingly, evidence from preclinical (in vitro and in vivo) and clinical studies opens new perspectives for development of pharmacological strategies to accelerate tissue repair. These therapies usually stimulate the synthesis of antioxidant proteins and accelerate the completion of the inflammatory process, as well as decreasing the oxidative stress in regenerating tissues.

This special issue aims to create an interdisciplinary platform involving morphological, physiological, and pathological issues to discuss the cellular and molecular basis of the metabolism redox associated with repair tissue. We welcome primary research articles (in silico, in vitro, and in vivo), as well as comprehensive and systematic review articles, that will illustrate and stimulate the continuing effort to understand the redox systems in tissue repair metabolism, biomarkers, and treatments.

Potential topics include but are not limited to the following:

  • Metabolism redox in tissue repair
  • Biomarkers of oxidative stress and antioxidant defenses during tissue repair
  • Therapies that act as antioxidants during the repair process
  • Analytical methods and instrumentation applied to the analysis of redox metabolism in tissue repair
  • Redox mechanisms involved in inflammatory processes during tissue repair
  • Redox mechanisms involved in regeneration and tissue healing processes

Articles

  • Special Issue
  • - Volume 2020
  • - Article ID 3675603
  • - Research Article

The Estimation of Blood Paramagnetic Center Changes during Burns Management with Biodegradable Propolis-Nanofiber Dressing

Pawel Olczyk | Katarzyna Komosinska-Vassev | ... | Barbara Pilawa
  • Special Issue
  • - Volume 2020
  • - Article ID 4586839
  • - Research Article

Safflor Yellow B Attenuates Ischemic Brain Injury via Downregulation of Long Noncoding AK046177 and Inhibition of MicroRNA-134 Expression in Rats

Chaoyun Wang | Hongzhi Wan | ... | Chunxiang Zhang
  • Special Issue
  • - Volume 2020
  • - Article ID 4951820
  • - Research Article

Huangbai Liniment Accelerated Wound Healing by Activating Nrf2 Signaling in Diabetes

Jingjing Zhang | Rui Zhou | ... | Hongjun Yang
  • Special Issue
  • - Volume 2020
  • - Article ID 5083876
  • - Review Article

Carbon Monoxide Being Hydrogen Sulfide and Nitric Oxide Molecular Sibling, as Endogenous and Exogenous Modulator of Oxidative Stress and Antioxidative Mechanisms in the Digestive System

Edyta Korbut | Tomasz Brzozowski | Marcin Magierowski
  • Special Issue
  • - Volume 2020
  • - Article ID 4293206
  • - Review Article

NLRP3 Inflammasome and Its Central Role in the Cardiovascular Diseases

Yeqing Tong | Zhihong Wang | ... | Jinquan Cheng
  • Special Issue
  • - Volume 2020
  • - Article ID 1817635
  • - Research Article

Preprotection of Tea Polysaccharides with Different Molecular Weights Can Reduce the Adhesion between Renal Epithelial Cells and Nano-Calcium Oxalate Crystals

Yao-Wang Zhao | Li Liu | ... | Jian-Ming Ouyang
  • Special Issue
  • - Volume 2019
  • - Article ID 7954657
  • - Research Article

Exosomal circHIPK3 Released from Hypoxia-Pretreated Cardiomyocytes Regulates Oxidative Damage in Cardiac Microvascular Endothelial Cells via the miR-29a/IGF-1 Pathway

Yan Wang | Ranzun Zhao | ... | Bei Shi
  • Special Issue
  • - Volume 2019
  • - Article ID 7463412
  • - Research Article

Potential Role of Nutrient Intake and Malnutrition as Predictors of Uremic Oxidative Toxicity in Patients with End-Stage Renal Disease

Robson E. Silva | Ana C. Simões-e-Silva | ... | Rômulo D. Novaes
  • Special Issue
  • - Volume 2019
  • - Article ID 3429635
  • - Research Article

Subacute Testicular Toxicity to Cadmium Exposure Intraperitoneally and Orally

Viviane G. S. Mouro | Ana L. P. Martins | ... | Sérgio L. P. Matta
  • Special Issue
  • - Volume 2019
  • - Article ID 3010342
  • - Review Article

Radiation-Induced Normal Tissue Damage: Oxidative Stress and Epigenetic Mechanisms

Jinlong Wei | Bin Wang | ... | Xin Jiang
Oxidative Medicine and Cellular Longevity
 Journal metrics
Acceptance rate48%
Submission to final decision56 days
Acceptance to publication37 days
CiteScore7.300
Impact Factor5.076
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