Oxidative Medicine and Cellular Longevity

Interplay between Oxidative Stress and Metabolism in Signalling and Disease


Status
Published

1Facultad de Medicina-Universidad de la República, Montevideo, Uruguay

2National Institutes of Health, Bethesda, USA

3University of Pittsburgh, Pittsburgh, USA


Interplay between Oxidative Stress and Metabolism in Signalling and Disease

Description

It has long been recognized that energy metabolism is linked to the production of reactive species and critical enzymatic processes allied to metabolic pathways can be affected by redox reactions. For example, both protein and lipid oxidation are involved in the aging process as well as the onset and progression of many age-related diseases. As such, the capacity to identify specific targets and detect subsequent oxidative modifications is crucial for our understanding of the molecular basis of age-related diseases (i.e., diabetes, metabolic syndrome, or atherosclerosis) and for revealing novel treatment strategies.

We are inviting investigators in the area of oxidative stress, cell signaling, and metabolism to contribute to this special issue with original research articles as well as review articles. Our aim is to augment our understanding of the interplay between metabolism and oxidative stress in cell signaling and disease. Articles may address the molecular mechanisms involved in this processes as well as their role in human diseases and cell physiology. Reports on novel methodological approaches in both in vitro and in vivo models will also be considered.

Potential topics include, but are not limited to:

  • Oxidative posttranslational modifications of mitochondrial proteins and lipids
  • Mitochondrial oxidants and antioxidants in cell signalling and dysfunction
  • mTOR signaling in aging and aging-related diseases
  • Sirtuins and oxidative stress
  • Formation and detection of reactive species in metabolic disorders

Articles

  • Special Issue
  • - Volume 2016
  • - Article ID 3274296
  • - Editorial

Interplay between Oxidative Stress and Metabolism in Signalling and Disease

Andrés Trostchansky | Celia Quijano | ... | Adriana Maria Cassina
  • Special Issue
  • - Volume 2016
  • - Article ID 3480637
  • - Research Article

Maladaptive Modulations of NLRP3 Inflammasome and Cardioprotective Pathways Are Involved in Diet-Induced Exacerbation of Myocardial Ischemia/Reperfusion Injury in Mice

Raffaella Mastrocola | Massimo Collino | ... | Manuela Aragno
  • Special Issue
  • - Volume 2016
  • - Article ID 9831825
  • - Review Article

Potential Modulation of Sirtuins by Oxidative Stress

Leonardo Santos | Carlos Escande | Ana Denicola
  • Special Issue
  • - Volume 2016
  • - Article ID 4010357
  • - Review Article

Dietary Restriction and Nutrient Balance in Aging

Júlia Santos | Fernanda Leitão-Correia | ... | Cecília Leão
  • Special Issue
  • - Volume 2016
  • - Article ID 9151290
  • - Research Article

Toll-Like Receptor 4 Reduces Oxidative Injury via Glutathione Activity in Sheep

Shoulong Deng | Kun Yu | ... | Zhengxing Lian
  • Special Issue
  • - Volume 2016
  • - Article ID 7843685
  • - Research Article

Correlation between Mitochondrial Reactive Oxygen and Severity of Atherosclerosis

Gabriel G. Dorighello | Bruno A. Paim | ... | Helena C. F. Oliveira
  • Special Issue
  • - Volume 2015
  • - Article ID 482582
  • - Review Article

Mitochondrial Retrograde Signaling: Triggers, Pathways, and Outcomes

Fernanda Marques da Cunha | Nicole Quesada Torelli | Alicia J. Kowaltowski
  • Special Issue
  • - Volume 2015
  • - Article ID 940627
  • - Research Article

Increased Susceptibility of Gracilinanus microtarsus Liver Mitochondria to Ca2+-Induced Permeability Transition Is Associated with a More Oxidized State of NAD(P)

Juliana A. Ronchi | Barbara Henning | ... | Anibal E. Vercesi
  • Special Issue
  • - Volume 2015
  • - Article ID 359315
  • - Research Article

Toll-Like Receptor 4 Promotes NO Synthesis by Upregulating GCHI Expression under Oxidative Stress Conditions in Sheep Monocytes/Macrophages

Shoulong Deng | Kun Yu | ... | Zhengxing Lian
  • Special Issue
  • - Volume 2015
  • - Article ID 839748
  • - Research Article

Insulin Therapy of Nondiabetic Septic Patients Is Predicted by para-Tyrosine/Phenylalanine Ratio and by Hydroxyl Radical-Derived Products of Phenylalanine

Szilárd Kun | Gergő A. Molnár | ... | István Wittmann
Oxidative Medicine and Cellular Longevity
 Journal metrics
Acceptance rate48%
Submission to final decision56 days
Acceptance to publication37 days
CiteScore7.300
Impact Factor5.076
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