Most cancer cell damage caused by oxidative stress is mainly caused by reactive oxygen species (ROS). Studies have shown that Notch, a classical signaling pathway, inhibits the expression of the P53 protein, which activates cellular oxidative stress and leads to cancer cell death. Meanwhile, downstream genes of the Notch pathway, including Myc and P21, among others, have been confirmed to be closely associated with cancer. The balance of oxidative stress plays a very important role in the inhibition and progression of cancer. ROS production can not only attack cancer cells but also reduce DNA stability and promote cancer progression. Therefore, we speculate whether Notch pathway may have an anti-cancer effect by regulating the oxidative stress pathway.

The Notch signaling pathway may be a potential drug target for cancer therapy. At present, the treatment of cancer, especially lung cancer, breast cancer, and kidney cancer, mainly relies on targeted drugs and PD-1 or CTLA-4 immunotherapy. Patients may experience increased drug resistance, side effects, and other problems after receiving treatment for a period of time. Researchers have been looking for targeted drugs that could potentially be used as new therapies. At present, there are few studies on the relationship between the Notch pathway and oxidative stress, and the application of the Notch pathway in cancer treatment is rarely reported. Therefore, it is of great significance to explore whether the Notch pathway can be used to treat cancer by regulating oxidative stress, which can provide more ideas for clinical cancer treatment.

The purpose of this Special Issue is to provide clinical treatment ideas for cancer, research and development of new targeted drugs, and research on the prognosis of cancer patients. We also hope to attract original research and review articles focusing on the relationship between Notch signaling and oxidative stress and its role in the prevention and treatment of many kinds of cancer. We encourage cell, animal, and clinical research, and we also welcome discussions on the links between the Notch pathway and other cancer-related molecules or pathways.

Potential topics include but are not limited to the following:

• The relationship between the Notch pathway and oxidative stress
• The molecular mechanisms of the Notch pathway influencing cell oxidation
• Notch signaling changes inducing cellular oxidative stress
• Regulation of cellular oxidative balance by the Notch pathway
• The Notch pathway and cancer therapy
• Application of the Notch pathway in anticancer drugs
• Effects of oxidative stress on cancer in cancers of obvious lipid metabolism
• Oxidative stress and new ideas for cancer therapy