Oxidative Medicine and Cellular Longevity

Hydrogen Peroxide in Adaptation

Publishing date
23 Nov 2012
Submission deadline
06 Jul 2012

Lead Editor

1Paterson Institute for Cancer Research, The University of Manchester, Manchester M20 4BX, UK

2Department of Biochemistry, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil

Hydrogen Peroxide in Adaptation


The initial perception of hydrogen peroxide (H2O2) and other reactive oxygen species as unwanted but unavoidable biproducts of aerobic existence was subdued during the past couple of decades by continuously emerging data showing their involvement in redox signalling. In parallel, another very important but less prominent aspect of H2O2 metabolism has been developing which concerns the role of H2O2 in adaptation. A number of studies have illustrated that, at concentrations in the high physiological range, H2O2 induces adaptive changes, increasing resistance of biological systems not only to oxidative stress but to many other stimuli as well. The capability of H2O2 to induce the synthesis of a large number of proteins and to provide cross-resistance implies that living systems may “intentionally”� produce H2O2 as a component of adaptation in response to different fluctuations and perturbations shifting the system away from homeostasis.

The aim of this issue is to make the next step in understanding the involvement of H2O2 and other reactive oxygen species in adaptation. We invite authors to help in creating what will represent a milestone in the field of redox physiology by presenting original research articles as well as reviews exploring and explaining different aspects of H2O2-mediated adaptation. Investigations performed on human material, cultured cells, animal model systems, yeast, and bacteria are eligible. We encourage authors to prepare evidence-based reviews with strong personal impact. Potential topics include, but are not limited to:

  • The effects of pretreatment with H2O2 on (multifaceted) adaptive responses
  • Adaptation systems and aging
  • Adaptation to cold and other types of environmental stress
  • Adaptation systems in exercise
  • Adaptation systems in hypoxia and cardiovascular conditions
  • Adaptation systems in nervous tissue
  • Adaptation systems and metal homeostasis
  • Adaptation systems and inflammatory response
  • Angiogenesis and wound healing
  • Cell cycle
  • Tumor progression and metastasis
  • Regulation of enzymatic activity
  • Regulation of transcription and translation
  • Characterisation of proteins whose synthesis is regulated by H2O2

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/oximed/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


  • Special Issue
  • - Volume 2012
  • - Article ID 596019
  • - Editorial

Hydrogen Peroxide in Adaptation

Ivan Spasojević | David R. Jones | Michael E. Andrades
  • Special Issue
  • - Volume 2012
  • - Article ID 105820
  • - Research Article

Reversible Oxidation of Myometrial Voltage-Gated Potassium Channels with Hydrogen Peroxide

Isabella Appiah | Aleksandra Nikolic-Kokic | ... | Dusko Blagojevic
  • Special Issue
  • - Volume 2012
  • - Article ID 740849
  • - Review Article

Mitochondrial Hormesis in Pancreatic β Cells: Does Uncoupling Protein 2 Play a Role?

Ning Li | Suzana Stojanovski | Pierre Maechler
  • Special Issue
  • - Volume 2012
  • - Article ID 564093
  • - Review Article

Formation and Regulation of Adaptive Response in Nematode Caenorhabditis elegans

Y.-L. Zhao | D.-Y. Wang
  • Special Issue
  • - Volume 2012
  • - Article ID 794237
  • - Review Article

Regulation of ROS Production and Vascular Function by Carbon Monoxide

Yoon Kyung Choi | Elaine D. Por | ... | Young-Myeong Kim
  • Special Issue
  • - Volume 2012
  • - Article ID 717843
  • - Review Article

The Role of Hydrogen Peroxide in Environmental Adaptation of Oral Microbial Communities

Lin Zhu | Jens Kreth
  • Special Issue
  • - Volume 2012
  • - Article ID 976753
  • - Review Article

Reactive Oxygen Species in the Signaling and Adaptation of Multicellular Microbial Communities

Michal Čáp | Libuše Váchová | Zdena Palková
  • Special Issue
  • - Volume 2012
  • - Article ID 569520
  • - Review Article

Cardiac Response to Chronic Intermittent Hypoxia with a Transition from Adaptation to Maladaptation: The Role of Hydrogen Peroxide

Xia Yin | Yang Zheng | ... | Lu Cai
Oxidative Medicine and Cellular Longevity
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