Oxidative Medicine and Cellular Longevity

The Potential Role of Exosomes and Oxidative Stress in Diabetes and Vascular Aging


Publishing date
01 Oct 2020
Status
Closed
Submission deadline
05 Jun 2020

Lead Editor

1Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing, China

2Tongji University, Shanghai, China

3The Chinese University of Hong Kong, Shatin, Hong Kong

This issue is now closed for submissions.
More articles will be published in the near future.

The Potential Role of Exosomes and Oxidative Stress in Diabetes and Vascular Aging

This issue is now closed for submissions.
More articles will be published in the near future.

Description

Accelerated vascular aging is a condition that occurs as a complication due to several highly prevalent cardiovascular and neurodegenerative diseases, including hypertension, coronary heart disease, heart failure, vascular dementia and Alzheimer’s disease (AD). It is widely recognized that cardiovascular diseases are the most significant factor which causes morbidity associated with diabetes. Emerging clinical evidence suggests that diabetes increases the risk of dementia, and although the mechanisms contributing to this increased morbidity are poorly understood, worsening of the risk factors partly contributes to the enhancement of vascular inflammation and atherosclerosis; the underlying mechanisms remain to be fully elucidated.

Studies in humans and experimental animal models highlight oxidative stress and inflammation as a critical element for diabetes in vascular aging and its consequent impact on cardiovascular and cerebrovascular diseases. Exosomes are reported to be involved in multiple pathological processes including atherosclerosis, chronic inflammation, and insulin resistance. Recent insights regarding the roles of exosome-associated genetic materials (microRNAs) and their regulation of oxidative stress and inflammation in vascular aging and diabetes have drawn a lot of attention. MicroRNAs regulate the physiological function and pathological processes of metabolic disorders and vascular aging. Therefore, they may also be useful as novel or potential diagnostics and therapeutics.

The Special Issue will focus on the targets of the microRNAs and the specific molecular pathways affected, in addition to their influence on both the blood vessels and the heart or brain, such as cardiovascular and chronic neurodegenerative diseases. Contributions are welcome in the form of original research and review articles that help to better understand the pathophysiological characteristics, mechanisms of drug action, novel diagnostics, and therapeutics contribute to the development and maintenance of vascular aging related diseases.

Potential topics include but are not limited to the following:

  • MicroRNAs and oxidative stress in diabetes and vascular aging related diseases, especially cardiovascular and/or neurodegenerative diseases
  • Novel or potential diagnostics and prognosis for diabetes and vascular aging related diseases, especially cardiovascular and/or neurodegenerative diseases
  • Mechanism or target prediction of potential therapeutics (medicinal plants are welcome) for diabetes and vascular aging related diseases, especially cardiovascular and/or neurodegenerative diseases based on network pharmacology
  • Meta-analysis of randomized controlled trials or primary clinical data to evaluate the efficacy, or otherwise, of novel or potential therapeutics (medicinal plants are welcome) for diabetes and vascular aging related diseases, especially cardiovascular and/or neurodegenerative diseases
  • Novel therapeutic strategies (medicinal plants are welcome) for diabetes and vascular aging related diseases (in vitro and in vivo studies), especially cardiovascular and/or neurodegenerative diseases
  • Oxidative stress connected with microRNAs in diabetes and vascular aging related disease

Articles

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Ningle Wei | Liuyi Lu | ... | Hui Huang
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Xiaoyu Wang | Yunxiang Zhou | ... | Anwen Shao
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Xing Chang | Tian Zhang | ... | Jiahui Sun
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Wen Yang | Yue Liu | ... | Zhi-Xiu Lin
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Shengjie Yang | Min Wu | ... | Songzi Wang
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Xue Wang | Jia-Qi Zhang | ... | Yan Lei
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Network Pharmacology to Uncover the Biological Basis of Spleen Qi Deficiency Syndrome and Herbal Treatment

Xin Wang | Min Wu | ... | Shao Li
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Extracts or Active Components from Acorus gramineus Aiton for Cognitive Function Impairment: Preclinical Evidence and Possible Mechanisms

Yan Li | Xi-Le Zhang | ... | Li-Ping Zhang
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  • - Article ID 8253904
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Acupuncture Attenuates Inflammation in Microglia of Vascular Dementia Rats by Inhibiting miR-93-Mediated TLR4/MyD88/NF-κB Signaling Pathway

Lu Wang | Jing-Wen Yang | ... | Cun-Zhi Liu
Oxidative Medicine and Cellular Longevity
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Acceptance rate48%
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CiteScore7.300
Impact Factor5.076
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