Metabolic disorders, such as type 2 diabetes, hyperlipidemia, obesity, and non-alcoholic fatty liver disease, are a class of diseases involving disturbance of metabolism. Oxidative stress-induced vascular injury and remodeling are dominant pathological features of the complications of metabolic disorders, including macro- and micro-vascular injury in the heart, brain, arms and legs, kidney, retina, and so on. The prevalence of metabolic vascular diseases has risen rapidly in recent years. Moreover, metabolic vascular diseases are major causes of blindness, kidney failure, heart attacks, stroke, and lower limb amputation and account for increased premature mortality globally.

Although metabolic disorder-induced oxidative stress plays a critical role in the progression of metabolic vascular diseases, clinical trials evaluating antioxidant supplements have thus far failed to improve metabolic vascular diseases. Recent studies have shown that oxidative stress could induce programmed cell death (apoptosis, pyroptosis, necroptosis, ferroptosis, and NETs) and activation of inflammation in various diseases and epigenetic modifications (such as noncoding RNAs, histone modification, DNA methylation, chromatin remodeling) and gut microbiota mediate new mechanisms in regulation of oxidative stress. However, the roles of the epigenetic modifications and gut microbiota in metabolic vascular diseases and novel drugs targeting oxidative stress based on these factors are still unknown.

In this Special Issue, we encourage investigators to submit original research and review articles focusing on the molecular mechanism of oxidative stress in the development of metabolic vascular diseases, the roles of epigenetic modifications, gut microbiota and, programmed cell death in redox balance regulation and metabolic vascular diseases, and novel drugs targeting oxidative stress in the treatment and prevention of metabolic vascular disease.

Potential topics include but are not limited to the following:

• Molecular mechanisms of oxidative stress in vascular injury and remodeling in metabolic vascular diseases
• Oxidative stress-induced programmed cell death, such as apoptosis, pyroptosis, necroptosis, ferroptosis, NETs, and autophagy et al., in metabolic vascular diseases
• The role of oxidative stress in regulating of inflammatory activation and resolution and metabolic vascular diseases
• Epigenetic modifications, such as noncoding RNAs, histone modification, DNA methylation, chromatin remodeling et al, in oxidative stress regulation and metabolic vascular diseases
• Gut microbiota and metabolites in oxidative stress regulation and metabolic vascular diseases
• Disturbance of glucose, lipids, and amino acid metabolism in oxidative stress and metabolic vascular diseases
• Novel drugs targeting oxidative stress for the prevention and treatment of metabolic vascular diseases
• Novel mechanisms of oxidative stress-induced endothelial dysfunction in diabetic vascular complications
• The role of high glucose-induced oxidative stress in angiogenesis dysfunction in diabetic foot ulcers