Oxidative Medicine and Cellular Longevity

Natural Bioactive Products with Antioxidant Properties Useful in Neurodegenerative Disease 2020


Publishing date
01 Sep 2020
Status
Closed
Submission deadline
24 Apr 2020

1State University of Paraiba, Campina Grande, Brazil

2Federal University of Paraiba, João Pessoa, Brazil

3Federal University of Paraiba, Campus I, PB, Brazil

4Vellore Institute of Technology, Tamilnadu, India

5University of North Carolina at Chapel Hill, North Carolina, USA

This issue is now closed for submissions.
More articles will be published in the near future.

Natural Bioactive Products with Antioxidant Properties Useful in Neurodegenerative Disease 2020

This issue is now closed for submissions.
More articles will be published in the near future.

Description

Neurodegenerative diseases (ND) constitute a large group of pathological conditions, characterized by progressive loss of neurons cells, which compromised motor and/or cognitive function. The most common ND are: Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS), Parkinson's disease (PD), and Huntington's disease (HD). The causes of these pathologies are multifactorial and not fully understood, but it is well known that factors related to aging and to the overproduction of free radical and reactive oxygen species lead to oxidative stress and to cell death, are extremely related. Whereas oxidative stress plays an unquestionable and central role in ND, the control of free radicals and reactive oxygen species levels represents an interesting and promising strategy to delay neurodegeneration and attenuate the associated symptoms.

In this context, several natural bioactive compounds isolated from plants, fungi, algae, among others, and also synthetic compounds inspired by natural scaffolds, which present antioxidant properties, including vitamins C and E, anthocyanins and phenolic compounds (flavonoids, coumarins, polyphenols), are extensively described as potential palliative agents of neurodegenerative symptoms. In vitro and in vivo studies performed with extracts and fractions of plants, and with isolated natural bioactive compounds evidence the role of these substances in the modulation of the cellular redox balance, and in the reduction of the formation of reactive oxygen species originating from oxidative stress, demonstrating thus its great value as antioxidant agents, and cellular protectors.

In this Special Issue, we invite researchers to contribute reviews, as well as original research articles concerning the use of natural bioactive compounds (extracts, fractions, or isolated compounds), and related synthetic compounds with antioxidant properties, useful in preventing the symptoms of aging and neurodegenerative disorders.

Potential topics include but are not limited to the following:

  • Use of natural bioactive compounds (extracts, fractions, or isolated compounds) with antioxidant activity for the treatment of neurodegenerative pathologies
  • Foods with antioxidant properties capable of ameliorating neurodegenerative symptoms
  • Use of natural products as prototypes of new antioxidant drugs for the treatment of neurodegenerative diseases
  • Theoretical and computational studies of natural and synthetic bioactive compounds against neurodegenerative diseases
  • Studies of the cellular and molecular mechanisms associated with oxidative stress generated by natural and synthetic bioactive products in NDs
  • Pharmacological and toxicological effects of natural bioactive compounds: in vitro and in vivo studies of NDs
  • Clinical or preclinical studies showing bioactive compounds properties in the treatment of NDs
  • Technological strategies used to enhance the effects of bioactive compounds against NDs

Articles

  • Special Issue
  • - Volume 2020
  • - Article ID 9268083
  • - Research Article

Curcumin Attenuates Chronic Unpredictable Mild Stress-Induced Depressive-Like Behaviors via Restoring Changes in Oxidative Stress and the Activation of Nrf2 Signaling Pathway in Rats

Dehua Liao | Chuanfeng Lv | ... | Pei Jiang
  • Special Issue
  • - Volume 2020
  • - Article ID 8648742
  • - Review Article

Identifying Plant-Based Natural Medicine against Oxidative Stress and Neurodegenerative Disorders

Rahul Chandran | Heidi Abrahamse
  • Special Issue
  • - Volume 2020
  • - Article ID 3098673
  • - Research Article

Identification of New Targets and the Virtual Screening of Lignans against Alzheimer’s Disease

Mayara dos Santos Maia | Gabriela Cristina Soares Rodrigues | ... | Francisco Jaime B. Mendonça-Junior
  • Special Issue
  • - Volume 2020
  • - Article ID 8908901
  • - Research Article

The Effects of Alpha-Linolenic Acid on the Secretory Activity of Astrocytes and β Amyloid-Associated Neurodegeneration in Differentiated SH-SY5Y Cells: Alpha-Linolenic Acid Protects the SH-SY5Y cells against β Amyloid Toxicity

Anna Litwiniuk | Anita Domańska | ... | Małgorzata Kalisz
  • Special Issue
  • - Volume 2020
  • - Article ID 1948602
  • - Research Article

Honeybush Extracts (Cyclopia spp.) Rescue Mitochondrial Functions and Bioenergetics against Oxidative Injury

Anastasia Agapouda | Veronika Butterweck | ... | Anne Eckert
  • Special Issue
  • - Volume 2020
  • - Article ID 6281454
  • - Review Article

Foods with Potential Prooxidant and Antioxidant Effects Involved in Parkinson’s Disease

Alejandra Guillermina Miranda-Díaz | Andrés García-Sánchez | Ernesto Germán Cardona-Muñoz
  • Special Issue
  • - Volume 2020
  • - Article ID 6069354
  • - Research Article

A Dihydroflavonoid Naringin Extends the Lifespan of C. elegans and Delays the Progression of Aging-Related Diseases in PD/AD Models via DAF-16

Qing Zhu | Yuan Qu | ... | Gui-Sheng Wu
  • Special Issue
  • - Volume 2020
  • - Article ID 3184019
  • - Research Article

Amarogentin from Gentiana rigescens Franch Exhibits Antiaging and Neuroprotective Effects through Antioxidative Stress

Dejene Disasa | Lihong Cheng | ... | Jianhua Qi
  • Special Issue
  • - Volume 2020
  • - Article ID 6125638
  • - Research Article

Olive Leaf Polyphenols Attenuate the Clinical Course of Experimental Autoimmune Encephalomyelitis and Provide Neuroprotection by Reducing Oxidative Stress, Regulating Microglia and SIRT1, and Preserving Myelin Integrity

Jasminka Giacometti | Tanja Grubić-Kezele
  • Special Issue
  • - Volume 2020
  • - Article ID 3481758
  • - Research Article

Hydroxy-α-sanshool Possesses Protective Potentials on H2O2-Stimulated PC12 Cells by Suppression of Oxidative Stress-Induced Apoptosis through Regulation of PI3K/Akt Signal Pathway

Ruo-Lan Li | Qing Zhang | ... | Chun-Jie Wu
Oxidative Medicine and Cellular Longevity
 Journal metrics
Acceptance rate48%
Submission to final decision56 days
Acceptance to publication37 days
CiteScore7.300
Impact Factor5.076
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