Associations between metabolism, inflammation, and oxidative stress play an important role in the development of age-related metabolic diseases, such as obesity, type 2 diabetes (T2D), and cardiovascular disease (CVD), as well as kidney diseases.

Cellular senescence is a hallmark of aging that can contribute to age-related metabolic diseases. The age-dependent cellular senescence of tissues has been linked to mitochondrial dysfunction and abnormal change in reactive oxygen species (ROS). Senescent cells and their secretory pro-inflammatory factors, the senescence-associated secretory phenotype (SASP), overlap with those secreted by dysfunctional tissues.

This Special Issue aims to provide an updated overview of associations between metabolism, inflammation, and oxidative stress in age-related metabolic diseases. Novel strategies are strongly desirable to interfere with inflammation and oxidative stress for blockage the onset of senescence and age-related pathologies in dysfunctional metabolisms. Original research and review articles are welcome.

Potential topics include but are not limited to the following:

• Sources and regulation of ROS in senescence and age-related diseases
• Mechanisms of oxidative stress-mediated signaling in inflammation
• Interaction between ROS production, inflammation, and senescence and age-related disorders
• Oxidative stress and tissue dysfunction
• Roles of anti- senescence and age-related inflammatory diseases and tissue dysfunction
• New strategies to interfere with inflammation and oxidative stress